Trends in liver transplantation for primary biliary cirrhosis in the Netherlands 1988-2008

BMC Gastroenterology

Research Article

Herold J Metselaar¹  Edith MM Kuiper¹  Robert A de Man¹  Henk R van Buuren¹  Bettina E Hansen²  Els B Haagsma³  Bart van Hoek⁴ 

[1] Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands;Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands;Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands;Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, The Netherlands;Department of Gastroenterology and Hepatology, University Medical Center Leiden, Leiden, The Netherlands;

关键词: Liver Transplantation;    Primary Biliary Cirrhosis;    Ursodeoxycholic Acid;    Spontaneous Bacterial Peritonitis;    Primary Biliary Cirrhosis Patient;   

DOI  :  10.1186/1471-230X-10-144

 received in 2010-03-25, accepted in 2010-12-20,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundA decrease in the need for liver transplantations (LTX) in Primary Biliary Cirrhosis (PBC), possibly related to treatment with ursodeoxycholic acid (UDCA), has been reported in the USA and UK. The aim of this study was to assess LTX requirements in PBC over the past 20 years in the Netherlands.MethodsAnalysis of PBC transplant data of the Dutch Organ Transplant Registry during the period 1988-2008, including both absolute and proportional numbers. The indication for LTX was categorized as liver failure, hepatocellular carcinoma or poor quality of life (severe fatigue or pruritus). Data were analysed for two decades: 1.1.1988-31.12.1997 (1st) and 1.1.1998-31.12.2007 (2nd). The severity of disease was quantified using MELD scores. To fit lines which show trends over time we applied a linear regression model.ResultsA total of 110 patients (87% women) was placed on the waiting list. 105 patients were transplanted (1st: 61, 2nd: 44), 5 (5%) died while listed. The absolute annual number of LTX for PBC slightly decreased during the 20 year period, the proportional number decreased significantly. At the time of LTX the mean age was 53.6 yrs. (1st: 53.4, 2nd: 53.8), the mean MELD score 13.9 (1st:14.5, 2nd:13.0). The median interval from diagnosis to LTX was 90.5 months (1st:86.5, 2nd: 93.5). 69% of patients was treated with UDCA (1st 38%, 2nd 82%).ConclusionsOver the past 20 years the absolute number of LTX for PBC in the Netherlands showed a tendency to decrease whereas the proportional decrease was significant. There was a trend over time toward earlier transplantation.

【 授权许可】

Unknown   
© Kuiper et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.