Nutrition Journal | |
Does Glycine max leaves or Garcinia Cambogiapromote weight-loss or lower plasma cholesterol in overweight individuals: a randomized control trial | |
Research | |
Robin A McGregor1  Seon-Min Jeon2  Myung-Sook Choi2  Ji-Eun Kim3  Ki Hun Park4  Woo Song Lee5  Tae-Sook Jeong6  | |
[1] Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, South Korea;Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, South Korea;Department of Food Science and Nutrition, Kyungpook National University, Daegu, South Korea;Department of Food Science and Nutrition, Kyungpook National University, Daegu, South Korea;Division of Applied Life Science (BK 21 Program), EB-NCRC, Institute of Agriculture and Life Science, Graduate School of Gyeongsang National University, Jinju, South Korea;Eco-Friendly Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, South Korea;National Research Laboratory of Lipid Metabolism & Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea; | |
关键词: atherosclerosis; cholesterol; clinical trial; hydroxyl citric acid; soybean leaves; weight-loss; | |
DOI : 10.1186/1475-2891-10-94 | |
received in 2011-04-13, accepted in 2011-09-21, 发布年份 2011 | |
来源: Springer | |
【 摘 要 】
BackgroundNatural food supplements with high flavonoid content are often claimed to promote weight-loss and lower plasma cholesterol in animal studies, but human studies have been more equivocal. The aim of this study was firstly to determine the effectiveness of natural food supplements containing Glycine max leaves extract (EGML) or Garcinia cambogia extract (GCE) to promote weight-loss and lower plasma cholesterol. Secondly to examine whether these supplements have any beneficial effect on lipid, adipocytokine or antioxidant profiles.MethodsEighty-six overweight subjects (Male:Female = 46:40, age: 20~50 yr, BMI > 23 < 29) were randomly assigned to three groups and administered tablets containing EGML (2 g/day), GCE (2 g/day) or placebo (starch, 2 g/day) for 10 weeks. At baseline and after 10 weeks, body composition, plasma cholesterol and diet were assessed. Blood analysis was also conducted to examine plasma lipoproteins, triglycerides, adipocytokines and antioxidants.ResultsEGML and GCE supplementation failed to promote weight-loss or any clinically significant change in %body fat. The EGML group had lower total cholesterol after 10 weeks compared to the placebo group (p < 0.05). EGML and GCE had no effect on triglycerides, non-HDL-C, adipocytokines or antioxidants when compared to placebo supplementation. However, HDL-C was higher in the EGML group (p < 0.001) after 10 weeks compared to the placebo group.ConclusionsTen weeks of EGML or GCE supplementation did not promote weight-loss or lower total cholesterol in overweight individuals consuming their habitual diet. Although, EGML did increase plasma HDL-C levels which is associated with a lower risk of atherosclerosis.
【 授权许可】
Unknown
© Kim et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
【 预 览 】
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