Associations between intensive diabetes therapy and NMR-determined lipoprotein subclass profiles in type 1 diabetes[S]

Journal of Lipid Research

Arpita Basu¹  Timothy J. Lyons²  Maria F. Lopes-Virella³  Ying Zhang³  Julie A. Stoner⁴  Richard L. Klein⁵  Alicia J. Jenkins⁶ 

[1] Centre for Experimental Medicine, Queen's University of Belfast, Northern Ireland, UK;Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC;Department of Biostatistics and Epidemiology University of Oklahoma Health Sciences Center, Oklahoma City, OK;Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK;Division of Endocrinology, Medical University of South Carolina, Charleston, SC;National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Camperdown, Sydney, NSW, Australia;

关键词: intensive diabetes treatment;    dyslipidemia;    atherosclerosis;    clinical trial;    high density lipoprotein;    low density lipoprotein;   

DOI  :  

来源: DOAJ

【 摘 要 】

Our objective is to define differences in circulating lipoprotein subclasses between intensive versus conventional management of type 1 diabetes during the randomization phase of the Diabetes Control and Complications Trial (DCCT). NMR-determined lipoprotein subclass profiles (NMR-LSPs), which estimate molar subclass concentrations and mean particle diameters, were determined in 1,294 DCCT subjects after a median of 5 years (interquartile range: 4–6 years) of randomization to intensive or conventional diabetes management. In cross-sectional analyses, we compared standard lipids and NMR-LSPs between treatment groups. Standard total, LDL, and HDL cholesterol levels were similar between randomization groups, while triglyceride levels were lower in the intensively treated group. NMR-LSPs showed that intensive therapy was associated with larger LDL diameter (20.7 vs. 20.6 nm, P = 0.01) and lower levels of small LDL (median: 465 vs. 552 nmol/l, P = 0.007), total IDL/LDL (mean: 1,000 vs. 1,053 nmol/l, P = 0.01), and small HDL (mean: 17.3 vs. 18.6 ¼mol/l, P < 0.0001), the latter accounting for reduced total HDL (mean: 33.8 vs. 34.8 ¼mol/l, P = 0.01). In conclusion, intensive diabetes therapy was associated with potentially favorable changes in LDL and HDL subclasses in sera. Further research will determine whether these changes contribute to the beneficial effects of intensive diabetes management on vascular complications.

【 授权许可】

Unknown