The impact of plasma triglyceride and apolipoproteins concentrations on high-density lipoprotein subclasses distribution

Lipids in Health and Disease

Research

Yanhua Xu¹  Tao Peng²  Shiyin Long³  Mingde Fu⁴  Yinghui Liu⁴  Li Tian⁴ 

[1] Chengdu Hoist Biotechnology Co.,LTD, 610075, Chengdu, Sichuan, PR China;Chengdu University Affiliated Hospital of Traditional Chinese Medicine, 610072, Chengdu, Sichuan, PR China;Department of Biochemistry and Molecular Biology, University of South China, Hengyang, Hunan, People’s Republic of China;Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China;

关键词: High Density Lipoprotein;    Cholesteryl Ester Transfer Protein;    Reverse Cholesterol Transport;    High Density Lipoprotein Particle;    High Density Lipoprotein Cholesterol Concentration;   

DOI  :  10.1186/1476-511X-10-17

 received in 2010-12-07, accepted in 2011-01-21,  发布年份 2011

来源: Springer

【 摘 要 】

ObjectiveTo investigate the effect of triglyceride (TG) integrates with plasma major components of apolipoproteins in HDL subclasses distribution and further elicited the TG-apolipoproteins (apos) interaction in the processes of high density lipoprotein (HDL) mature metabolic and atherosclerosis related diseases.MethodsContents of plasma HDL subclasses were quantities by two-dimensional gel electrophoresis associated with immunodetection in 500 Chinese subjects.ResultsContents of preβ1-HDL, HDL3a, and apoB-100 level along with apoB-100/A-I ratio were significantly increased, whereas there was a significant reduction in the contents of HDL2, apoA-I level as well as apoC-III/C-II ratio with increased TG concentration. Moreover, preβ1-HDL contents is elevated about 9 mg/L and HDL2b contents can be reduced 21 mg/L for 0.5 mmol/L increment in TG concentration. Moreover, with increase of apoA-I levels, HDL2b contents were marginally elevated in any TG concentration group. Furthermore, despite of in the apoB-100/A-I < 0.9 group, the contents of preβ1-HDL increased, and those of HDL2b decreased significantly for subjects in both high and very high TG levels compared to that in normal TG levels. Similarly, in the apoB-100/A-I ≥ 0.9 group, the distribution of HDL subclasses also showed abnormality for subjects with normal TG levels.ConclusionsThe particle size of HDL subclasses tend to small with TG levels increased which indicated that HDL maturation might be impeded and efficiency of reverse cholesterol transport(RCT) might be weakened. These data suggest that TG levels were not only significantly associated with but liner with the contents of preβ1-HDL and HDL2b. They also raise the possibility that the TG levels effect on HDL maturation metabolism are subjected to plasma apolipoproteins and apolipoproteins ratios.

【 授权许可】

Unknown   
© Tian et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.