Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women

Nutrition Journal

Short Report

Leon J Schurgers¹  Toshiro Sato²  Kazuhiro Uenishi³ 

[1]Department of Biochemistry, Cardiovascular Research Institute, University Maastricht, Maastricht, The Netherlands

[2]Fine Chemical Laboratory, J-OIL MILLS, INC, 1746 Nakashinden, 437-1111, Fukuroi-city, Shizuoka, Japan

[3]Laboratory of Physiological Nutrition, Kagawa Nutrition University, 3-9-2, Chiyoda, 350-0288, Sakado, Saitama, Japan

关键词: Vitamin K;    Menaquinone-4;    Menaquinone-7;    Bioavailability;    Absorption;   

DOI  :  10.1186/1475-2891-11-93

 received in 2012-07-17, accepted in 2012-11-03,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundVitamin K2 contributes to bone and cardiovascular health. Therefore, two vitamin K2 homologues, menaquinone-4 (MK-4) and menaquinone-7 (MK-7), have been used as nutrients by the food industry and as nutritional supplements to support bone and cardiovascular health. However, little is known about the bioavailability of nutritional MK-4. To investigate MK-4 and MK-7 bioavailability, nutritional doses were administered to healthy Japanese women.FindingsSingle dose administration of MK-4 (420 μg; 945 nmol) or MK-7 (420 μg; 647 nmol) was given in the morning together with standardized breakfast. MK-7 was well absorbed and reached maximal serum level at 6 h after intake and was detected up to 48 h after intake. MK-4 was not detectable in the serum of all subjects at any time point. Consecutive administration of MK-4 (60 μg; 135 nmol) or MK-7 (60 μg; 92 nmol) for 7 days demonstrated that MK-4 supplementation did not increase serum MK-4 levels. However, consecutive administration of MK-7 increased serum MK-7 levels significantly in all subjects.ConclusionsWe conclude that MK-4 present in food does not contribute to the vitamin K status as measured by serum vitamin K levels. MK-7, however significantly increases serum MK-7 levels and therefore may be of particular importance for extrahepatic tissues.

【 授权许可】

CC BY   
© Sato et al.; licensee BioMed Central Ltd. 2012