Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: interactive effect of MMP9 level

BMC Medical Genetics

Research Article

Yu-Chen Sun¹  Semon Wu²  Ming-Sheng Teng³  Hsien-Hsun Chang³  Hsuan-Pu Chen⁴  Jeng-Feng Lin⁵  Yu-Lin Ko⁶  Lung-An Hsu⁷ 

[1] Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan;Department of Life Science, Chinese Culture University, Taipei, Taiwan;Department of Medical Research, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan;Department of Medical Research, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan;Department of Neurology, University of California, San Francisco, USA;Division of Cardiology, Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Taipei branch, 289 Jianguo Road, 231, Xindian City, Taipei, Taiwan;Division of Cardiology, Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Taipei branch, 289 Jianguo Road, 231, Xindian City, Taipei, Taiwan;School of Medicine, Tzu Chi University, Hualien, Taiwan;The First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan;Chang Gung University College of Medicine, Taipei, Taiwan;

关键词: E-selectin;    Genetic association study;    Polymorphism;    Matrix metalloproteinase 9;    Haplotype;    Interaction;   

DOI  :  10.1186/1471-2350-13-115

 received in 2012-06-30, accepted in 2012-11-20,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundE-selectin is implicated in various inflammatory processes and related disorders. We aimed to investigate the role of SELE-gene genotypes/haplotypes on plasma levels of MMP9 and sE-selectin in Taiwanese individuals.MethodsFive hundred twenty individuals were enrolled. Seven tagging SELE single nucleotide polymorphisms were analyzed.ResultsSELE genotypes were found associated with MMP9 and sE-selectin levels. Multivariate analysis identified that the most significant genetic polymorphism (rs5368 genotype) was independently associated with MMP9 levels (P < 0.001). One haplotype (GGAGAGT) was marginally associated with MMP9 levels (P = 0.0490). One SELE SNP, (rs3917406, P = 0.031) was associated with sE-selectin levels after adjusting for MMP9 and sICAM1 levels. Subgroup and interaction analysis revealed association of SELE SNP rs10800469 with sE-selectin levels only in the highest quartile of MMP9 level (P = 0.002, interaction P = 0.023). Haplotype analysis showed one haplotype (AAAAAGC) borderline associated with sE-selectin level (P = 0.0511).ConclusionSELE genotypes/haplotypes are independently associated with MMP9 and E-selectin levels in Taiwanese individuals. The associations of SELE genotypes/haplotypes with sE-selectin levels are affected by MMP9 levels.

【 授权许可】

Unknown   
© Wu et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.