Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: interactive effect of MMP9 level

BMC Medical Genetics

Yu-Lin Ko⁶  Hsuan-Pu Chen⁵  Yu-Chen Sun¹  Hsien-Hsun Chang²  Jeng-Feng Lin³  Ming-Sheng Teng²  Lung-An Hsu⁴  Semon Wu² 

[1] Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan;Department of Medical Research, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan;Division of Cardiology, Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Taipei branch, 289 Jianguo Road, Xindian City, Taipei, 231, Taiwan;Chang Gung University College of Medicine, Taipei, Taiwan;Department of Neurology, University of California, San Francisco, USA;School of Medicine, Tzu Chi University, Hualien, Taiwan

关键词: Interaction;    Haplotype;    Matrix metalloproteinase 9;    Polymorphism;    Genetic association study;    E-selectin;   

Others  :  1177765
DOI  :  10.1186/1471-2350-13-115

 received in 2012-06-30, accepted in 2012-11-20,  发布年份 2012

【 摘 要 】

Background

E-selectin is implicated in various inflammatory processes and related disorders. We aimed to investigate the role of SELE-gene genotypes/haplotypes on plasma levels of MMP9 and sE-selectin in Taiwanese individuals.

Methods

Five hundred twenty individuals were enrolled. Seven tagging SELE single nucleotide polymorphisms were analyzed.

Results

SELE genotypes were found associated with MMP9 and sE-selectin levels. Multivariate analysis identified that the most significant genetic polymorphism (rs5368 genotype) was independently associated with MMP9 levels (P < 0.001). One haplotype (GGAGAGT) was marginally associated with MMP9 levels (P = 0.0490). One SELE SNP, (rs3917406, P = 0.031) was associated with sE-selectin levels after adjusting for MMP9 and sICAM1 levels. Subgroup and interaction analysis revealed association of SELE SNP rs10800469 with sE-selectin levels only in the highest quartile of MMP9 level (P = 0.002, interaction P = 0.023). Haplotype analysis showed one haplotype (AAAAAGC) borderline associated with sE-selectin level (P = 0.0511).

Conclusion

SELE genotypes/haplotypes are independently associated with MMP9 and E-selectin levels in Taiwanese individuals. The associations of SELE genotypes/haplotypes with sE-selectin levels are affected by MMP9 levels.

【 授权许可】

   
2012 Wu et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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