A local effect model-based interpolation framework for experimental nanoparticle radiosensitisation data

Cancer Nanotechnology

Research

Jeremy M. C. Brown¹  Fred J. Currell¹ 

[1] School of Mathematics and Physics, Queen’s University Belfast, Belfast, Northern Ireland, UK;

关键词: Gold nanoparticles;    Local effect model (LEM);    Radiosensitisers;    Radiotherapy;    Biological effect modelling;   

DOI  :  10.1186/s12645-016-0025-6

 received in 2016-11-15, accepted in 2016-12-20,  发布年份 2017

来源: Springer

【 摘 要 】

A local effect model (LEM)-based framework capable of interpolating nanoparticle-enhanced photon-irradiated clonogenic cell survival fraction measurements as a function of nanoparticle concentration was developed and experimentally benchmarked for gold nanoparticle (AuNP)-doped bovine aortic endothelial cells (BAECs) under superficial kilovoltage X-ray irradiation. For three different superficial kilovoltage X-ray spectra, the BAEC survival fraction response was predicted for two different AuNP concentrations and compared to experimental data. The ability of the developed framework to predict the cell survival fraction trends is analysed and discussed. This developed framework is intended to fill in the existing gaps of individual cell line response as a function of NP concentration under photon irradiation and assist the scientific community in planning future pre-clinical trials of high Z nanoparticle-enhanced photon radiotherapy.

【 授权许可】

CC BY   
© The Author(s) 2017

【 图 表 】

12951_2015_155_Article_IEq20.gif

12951_2015_155_Article_IEq19.gif

12951_2015_155_Article_IEq18.gif

12951_2015_155_Article_IEq16.gif

12951_2015_155_Article_IEq14.gif

12951_2015_155_Article_IEq12.gif

Fig. 2

12951_2015_155_Article_IEq9.gif

Fig. 2

Fig. 7

Fig. 1

Fig. 9

Fig. 9

Fig. 9

Fig. 4

Fig. 3

Fig. 4

Fig. 2

12951_2017_270_Article_IEq3.gif

Fig. 1