Age modifies the genotype-phenotype relationship for the bitter receptor TAS2R38

BMC Genetics

Research Article

Danielle R Reed¹  Fujiko F Duke¹  Julie A Mennella¹  M Yanina Pepino¹ 

[1] Monell Chemical Senses Center, 3500 Market St, 19104, Philadelphia, PA, USA;

关键词: Bitter Taste;    Taste Receptor;    Androstenone;    Taste Sensitivity;    Prop Threshold;   

DOI  :  10.1186/1471-2156-11-60

 received in 2009-07-16, accepted in 2010-07-01,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThe purpose of this study was to investigate the effect of TAS2R38 haplotypes and age on human bitter taste perception.ResultsChildren (3 to 10 yrs), adolescents (11 to 19 yrs) and adults (mostly mothers, 20 to 55 yrs (N = 980) were measured for bitter taste thresholds for 6-n-propylthiouracil (PROP) and genotyped for three polymorphisms of the AS2R38 gene (A49P, V262A, I296V). Subjects were grouped by haplotype and age, as well as sex and race/ethnicity, and compared for PROP thresholds. Subjects with the same haplotype were similar in bitter threshold regardless of race/ethnicity (all ages) or sex (children and adolescents; all p-values > 0.05) but age was a modifier of the genotype-phenotype relationship. Specifically, AVI/PAV heterozygous children could perceive a bitter taste at lower PROP concentrations than could heterozygous adults, with the thresholds of heterozygous adolescents being intermediate (p < 0.001). Similar age effects were not observed for subjects with the PAV/PAV or AVI/AVI homozygous haplotypes (p > 0.05) perhaps because there is less variation in taste perception among these homozygotes.ConclusionsThese data imply that the change in PROP bitter sensitivity which occurs over the lifespan (from bitter sensitive to less so) is more common in people with a particular haplotype combination, i.e., AVI/PAV heterozygotes.

【 授权许可】

Unknown   
© Mennella et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.