A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer

BMC Medical Genetics

Research Article

Maura Carrai¹  Roberto Barale¹  Jan Novotny²  Kari Hemminki³  Federico Canzian³  Asta Försti³  Daniele Campa⁴  Alessio Naccarati⁵  Pavel Vodicka⁵  Barbara Pardini⁵  Ludmila Vodickova⁵ 

[1] Department of Biology, University of Pisa, Pisa, Italy;Department of Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic;German Cancer Research Center (DKFZ), Heidelberg, Germany;German Cancer Research Center (DKFZ), Heidelberg, Germany;Department of Biology, University of Pisa, Pisa, Italy;Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic;

关键词: Bitter Taste;    Aristolochic Acid;    Colorectal Cancer Risk;    Light Smoker;    Luminal Content;   

DOI  :  10.1186/1471-2350-11-88

 received in 2009-11-04, accepted in 2010-06-09,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundMolecular sensing in the gastro-intestinal (GI) tract is responsible for the detection of ingested harmful drugs and toxins, thereby genetic polymorphisms affecting the capability of initiating these responses may be critical for the subsequent efficiency of the gut in eliminating possible threats to the organism. Although these fundamental control systems have been known for long time, the initial molecular recognition events that sense the chemical composition of the luminal contents of the GI tract have remained elusive. TAS2R14 is one of the better characterized members of the taste receptor family and has several polymorphic variants. Several substances that have been shown to activate TAS2R14 are powerful toxic and carcinogenic agents.MethodsUsing a tagging approach we investigated all the common genetic variation of the gene region in relation to colon cancer risk with a case-control study design. This is, at the best of our knowledge also the first report on the allele frequencies of the gene in the Caucasian population.ResultsWe found no evidence of statistically significant associations between polymorphisms in the TAS2R14 gene and colon cancer risk.ConclusionIn conclusion we can confidently exclude a major role for common polymorphisms of the TAS2R14 gene in colorectal cancer risk in this population, although in this report we had insufficient statistical power to completely exclude the possibility that rare variants of the TAS2R14 might be involved in colorectal cancer risk.

【 授权许可】

CC BY   
© Campa et al; licensee BioMed Central Ltd. 2010