Image quality in whole-body MRI using the MY-RADS protocol in a prospective multi-centre multiple myeloma study

Insights into Imaging

Original Article

Sadie Roberts¹  Sarah Brown¹  Gordon Cook²  Nuria Porta³  Antonio Candito⁴  Matthew Blackledge⁴  Amy Davis⁵  Aarti Shah⁶  Joshua Shur⁷  Erica Scurr⁷  Alina Dragan⁷  Dow-Mu Koh⁸  Jessica M. Winfield⁸  Mihaela Rata⁸  Martin Kaiser⁸  Christina Messiou⁸  Sam Keaveney⁸  Paul Malcolm⁹  Sanjay Gandhi^1,10  Mauro Albrizio^1,11  Arnold Drury^1,12  Alexander King^1,13  Matthew Jenner^1,13  Guy Pratt^1,14  Priya Suresh^1,15  Winston Rennie^1,16  Suchi Gaba^1,17  Anjumara Nilak^1,18 

[1] Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK;Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK;Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK;Clinical Trials and Statistics Unit, The Institute of Cancer Research, London, UK;Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK;Epsom & St. Helier University Hospitals NHS Trust, Epsom, UK;Hampshire Hospitals NHS Foundation Trust, Basingstoke, UK;MRI Unit, The Royal Marsden NHS Foundation Trust, London, UK;MRI Unit, The Royal Marsden NHS Foundation Trust, London, UK;Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK;Norfolk & Norwich University Hospitals NHS Foundation Trust, Norwich, UK;North Bristol NHS Trust, Bristol, UK;Nottingham University Hospitals NHS Trust, Nottingham, UK;Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust, Bournemouth, UK;University Hospital Southampton NHS Foundation Trust, Southampton, UK;University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK;University Hospitals Plymouth NHS Trust, Plymouth, UK;University Hospitals of Leicester NHS Trust, Leicester, UK;University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK;Worcestershire Acute Hospitals NHS Trust, Worcester, UK;

关键词: Whole-body MRI;    Myeloma;    Multi-centre trial;    Quality control;   

DOI  :  10.1186/s13244-023-01498-3

 received in 2023-05-11, accepted in 2023-08-08,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe Myeloma Response Assessment and Diagnosis System (MY-RADS) guidelines establish a standardised acquisition and analysis pipeline for whole-body MRI (WB-MRI) in patients with myeloma. This is the first study to assess image quality in a multi-centre prospective trial using MY-RADS.MethodsThe cohort consisted of 121 examinations acquired across ten sites with a range of prior WB-MRI experience, three scanner manufacturers and two field strengths. Image quality was evaluated qualitatively by a radiologist and quantitatively using a semi-automated pipeline to quantify common artefacts and image quality issues. The intra- and inter-rater repeatability of qualitative and quantitative scoring was also assessed.ResultsQualitative radiological scoring found that the image quality was generally good, with 94% of examinations rated as good or excellent and only one examination rated as non-diagnostic. There was a significant correlation between radiological and quantitative scoring for most measures, and intra- and inter-rater repeatability were generally good.When the quality of an overall examination was low, this was often due to low quality diffusion-weighted imaging (DWI), where signal to noise ratio (SNR), anterior thoracic signal loss and brain geometric distortion were found as significant predictors of examination quality.ConclusionsIt is possible to successfully deliver a multi-centre WB-MRI study using the MY-RADS protocol involving scanners with a range of manufacturers, models and field strengths. Quantitative measures of image quality were developed and shown to be significantly correlated with radiological assessment. The SNR of DW images was identified as a significant factor affecting overall examination quality.Trial registrationClinicalTrials.gov, NCT03188172, Registered on 15 June 2017.Critical relevance statementGood overall image quality, assessed both qualitatively and quantitatively, can be achieved in a multi-centre whole-body MRI study using the MY-RADS guidelines.Key points• A prospective multi-centre WB-MRI study using MY-RADS can be successfully delivered.• Quantitative image quality metrics were developed and correlated with radiological assessment.• SNR in DWI was identified as a significant predictor of quality, allowing for rapid quality adjustment.Graphical Abstract

【 授权许可】

CC BY   
© European Society of Radiology (ESR) 2023

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