Setting up a quantitative SPECT imaging network for a European multi-centre dosimetry study of radioiodine treatment for thyroid cancer as part of the MEDIRAD project

EJNMMI Physics

Manuel Bardiès¹  Alex Vergara Gil¹  Tino Schurrat²  Johannes Tran-Gia³  Michael Lassmann³  Uta Eberlein³  Susanne Schlögl³  Delphine Vallot⁴  Francesca Leek⁵  Glenn D. Flux⁵  Jan Taprogge⁵ 

[1] Centre de Recherches en Cancérologie de Toulouse, UMR 1037, INSERM, Université Paul Sabatier, Toulouse, France;Department of Nuclear Medicine, Philipps-University Marburg, Baldingerstrasse, 35043, Marburg, Germany;Department of Nuclear Medicine, University of Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany;IUCT Oncopole, Av. Irène Joliot-Curie, 31100, Toulouse, France;Joint Department of Physics, Royal Marsden NHSFT, Downs Road, SM2 5PT, Sutton, UK;The Institute of Cancer Research, 123 Old Brompton Road, SW7 3RP, London, UK;

关键词: Multi-centre trial;    Dosimetry;    Radioiodine;    Differentiated thyroid cancer;   

DOI  :  10.1186/s40658-020-00332-9

来源: Springer

【 摘 要 】

BackgroundDifferentiated thyroid cancer has been treated with radioiodine for almost 80 years, although controversial questions regarding radiation-related risks and the optimisation of treatment regimens remain unresolved. Multi-centre clinical studies are required to ensure recruitment of sufficient patients to achieve the statistical significance required to address these issues. Optimisation and standardisation of data acquisition and processing are necessary to ensure quantitative imaging and patient-specific dosimetry.Material and methodsA European network of centres able to perform standardised quantitative imaging of radioiodine therapy of thyroid cancer patients was set-up within the EU consortium MEDIRAD. This network will support a concurrent series of clinical studies to determine accurately absorbed doses for thyroid cancer patients treated with radioiodine. Five SPECT(/CT) systems at four European centres were characterised with respect to their system volume sensitivity, recovery coefficients and dead time.ResultsSystem volume sensitivities of the Siemens Intevo systems (crystal thickness 3/8″) ranged from 62.1 to 73.5 cps/MBq. For a GE Discovery 670 (crystal thickness 5/8″) a system volume sensitivity of 92.2 cps/MBq was measured. Recovery coefficients measured on three Siemens Intevo systems show good agreement. For volumes larger than 10 ml, the maximum observed difference between recovery coefficients was found to be ± 0.02. Furthermore, dead-time coefficients measured on two Siemens Intevo systems agreed well with previously published dead-time values.ConclusionsResults presented here provide additional support for the proposal to use global calibration parameters for cameras of the same make and model. This could potentially facilitate the extension of the imaging network for further dosimetry-based studies.

【 授权许可】

CC BY