Brain tumours and cigarette smoking: analysis of the INTERPHONE Canada case–control study

Environmental Health

Research

Mary McBride¹  Lesley Richardson²  Jack Siemiatycki³  Marie-Elise Parent⁴  Stephen Vida⁵  Michal Abrahamowicz⁵  Karen Leffondré⁶  Elisabeth Cardis⁷  Daniel Krewski⁸ 

[1] British Columbia Cancer Agency, Vancouver, Canada;Centre de Recherche, Centre hospitalier de l’Université de Montréal (CHUM), Montréal, Québec, Canada;Centre de Recherche, Centre hospitalier de l’Université de Montréal (CHUM), Montréal, Québec, Canada;Guzzo-SRC Research Chair in Environment and Cancer, Centre de Recherche, Centre hospitalier de l’Université de Montréal (CHUM), 850, rue St-Denis, room S02-458, H2X 0A9, Montreal, Quebec, Canada;Centre de Recherche, Centre hospitalier de l’Université de Montréal (CHUM), Montréal, Québec, Canada;INRS-Institut Armand-Frappier, Université du Québec, Laval, Québec, Canada;Centre de Recherche, Centre hospitalier de l’Université de Montréal (CHUM), Montréal, Québec, Canada;McGill University, Montréal, Québec, Canada;Centre de Recherche, Centre hospitalier de l’Université de Montréal (CHUM), Montréal, Québec, Canada;University of Bordeaux, ISPED, Centre INSERM U897-Epidemiology-Biostatistics, Bordeaux, France;Centre for Research in Environmental Epidemiology (CREAL), Municipal Institute of Medical Research (IMIM), CIBERESP, Barcelona, Spain;McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada;

关键词: Glioma;    Meningioma;    Brain tumours;    Cigarette;    Smoking;    Cigarette smoking;   

DOI  :  10.1186/1476-069X-13-55

 received in 2014-05-12, accepted in 2014-06-23,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThere is conflicting evidence regarding the associations between cigarette smoking and glioma or meningioma. Our purpose is to provide further evidence on these possible associations.MethodsWe conducted a set of case–control studies in three Canadian cities, Montreal, Ottawa and Vancouver. The study included 166 subjects with glioma, 93 subjects with meningioma, and 648 population-based controls. A lifetime history of cigarette smoking was collected and various smoking indices were computed. Multivariable logistic regression was used to estimate odds ratios (ORs) between smoking and each of the two types of brain tumours.ResultsAdjusted ORs between smoking and each type of brain tumour were not significantly elevated for all smokers combined or for smokers with over 15 pack-years ((packs / day) x years) accumulated. We tested for interactions between smoking and several sociodemographic variables; the interaction between smoking and education on glioma risk was significant, with smoking showing an elevated OR among subjects with lower education and an OR below unity among subjects with higher education.ConclusionExcept for an unexplained and possibly artefactual excess risk in one population subgroup, we found little or no evidence of an association between smoking and either glioma or meningioma.

【 授权许可】

Unknown   
© Vida et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.