Lactobacilli-Host mutualism: "learning on the fly"

Microbial Cell Factories

Proceedings

François Leulier¹  Renata C Matos¹ 

[1] Institut de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, CNRS UMR 5242, Université Claude Bernard Lyon 1, 46 Allée d'Italie, 69364 Cedex 07, Lyon, France;

关键词: Microbiota;    Lactobacillus;    Drosophila;    Mutualism;   

DOI  :  10.1186/1475-2859-13-S1-S6

来源: Springer

【 摘 要 】

Metazoans establish with microorganisms complex interactions for their mutual benefits. Drosophila, which has already proven useful host model to study several aspects of innate immunity and host-bacteria pathogenic associations has become a powerful model to dissect the mechanisms behind mutualistic host-microbe interactions. Drosophila microbiota is composed of simple and aerotolerant bacterial communities mostly composed of Lactobacillaceae and Acetobactereaceae. Drosophila mono- or poly-associated with lactobacilli strains constitutes a powerful model to dissect the complex interplay between lactobacilli and host biologic traits. Thanks to the genetic tractability of both Drosophila and lactobacilli this association model offers a great opportunity to reveal the underlying molecular mechanisms. Here, we review our current knowledge about how the Drosophila model is helping our understanding of how lactobacilli shapes host biology.

【 授权许可】

CC BY   
© Matos and Leulier; licensee BioMed Central Ltd. 2014