Multicenter analysis of epidemiological and clinical features of pediatric acute lower respiratory tract infections associated with common human coronaviruses in China, 2014–2019

Virology Journal

Research

Kunling Shen¹  Lili Xu²  Junhong Ai²  Shuaibing Han²  Yun Zhu²  Zhengde Xie²  Qianyu Feng²  Ziheng Feng²  Zhou Fu³  Ling Cao⁴  Baoping Xu⁵  Li Deng⁶  Rong Jin⁷  Yunxiao Shang⁸  Changchong Li⁹  Zhiming Chen^1,10  Yun Sun^1,11 

[1] Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, 100045, Beijing, China;Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, 100045, Beijing, China;Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, 100045, Beijing, China;Children’s Hospital of Chongqing Medical University, 400015, Chongqing, China;Children’s Hospital, Capital Institute of Pediatrics, 100020, Beijing, China;Department of Respiratory Diseases I, Beijing Children’s Hospital, Capital Medical University, National Clinical Research Center for Respiratory Diseases, National Center for Children’s Health, 100045, Beijing, China;Guangzhou Women and Children’s Medical Center, 510623, Guangzhou, China;Guiyang Women and Children Healthcare Hospital, 550003, Guiyang, China;Shengjing Hospital of China Medical University, 110004, Shenyang, China;The 2nd Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, 325027, Wenzhou, China;The Children’s Hospital of Zhejiang University School of Medicine, 310005, Hangzhou, China;Yinchuan Maternal and Child Health Hospital, 750000, Yinchuan, China;

关键词: Common human coronavirus;    Children;    Epidemiology;    Clinical manifestation;    Multicentre research;   

DOI  :  10.1186/s12985-023-02198-6

 received in 2023-04-20, accepted in 2023-10-02,  发布年份 2023

来源: Springer

【 摘 要 】

The common human coronaviruses (HCoVs) HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1 which are members of the coronavirus family are long co-existed with humans and widely distributed globally. Common HCoVs usually cause mild, self-limited upper respiratory tract infections (URTI), and also associated with lower respiratory tract infections (LRTI), especially in children. However, there are little multicentre studies have been conducted in children of several different areas in China, and the epidemic potential of common HCoVs remains unclear. Understanding of the common HCoVs is valuable for clinical and public health. Herein, we retrospectively analysed the medical records of children with acute lower respiratory tract infection admitted to 9 hospitals from different regions in China from 2014 to 2019. Of the 124 patients who tested positive for coronaviruses, OC43 was the predominant type, accounting for 36.3% (45/124) of the detections. Children aged ≤ 6 months and 12–23 months had the highest detection rate of common HCoVs, and the detection rate gradually declined after 2 years old. These four HCoVs could be detected all year round. Among the areas of our study, the overall positive rate was higher in southern China, especially in Guangzhou (29/124, 23.4%). Moreover, common HCoV-positive patients were codetected with 9 other common respiratory pathogens. 229E (11/13, 84.6%) was the most frequently associated with codetection, with EV/RhV was the most frequently codetected virus. Cough (113/124, 91.1%) and fever (73/124, 58.9%) were the most common symptoms of common HCoVs infection.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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