Prioritizing disease-related genes and pathways by integrating patient-specific iPSC-derived RNA-seq and whole genome sequencing in hypoplastic left heart syndrome

BMC Bioinformatics

Poster Presentation

Jean-Pierre Kocher¹  Xing Li¹  Almudena Martinez-Fernandez²  Jeanne Theis²  Andre Terzic³  Timothy J Nelson⁴  Timothy Olson⁵ 

[1] Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 55905, Rochester, MN, USA;Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, 55905, Rochester, MN, USA;Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, 55905, Rochester, MN, USA;Center for Regenerative Medicine, Mayo Clinic, 55905, Rochester, MN, USA;Transplant Center, Mayo Clinic, 55905, Rochester, MN, USA;Division of General Internal Medicine, Department of Medicine, Mayo Clinic, 55905, Rochester, MN, USA;Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, 55905, Rochester, MN, USA;Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 55905, Rochester, MN, USA;Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, 55905, Rochester, MN, USA;Center for Regenerative Medicine, Mayo Clinic, 55905, Rochester, MN, USA;Transplant Center, Mayo Clinic, 55905, Rochester, MN, USA;Division of General Internal Medicine, Department of Medicine, Mayo Clinic, 55905, Rochester, MN, USA;Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, 55905, Rochester, MN, USA;Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, 55905, Rochester, MN, USA;Division of General Internal Medicine, Department of Medicine, Mayo Clinic, 55905, Rochester, MN, USA;

关键词: Pluripotent Stem Cell;    Whole Genome Sequencing;    Congenital Heart Defect;    iPSC;    Hypoplastic Left Heart Syndrome;   

DOI  :  10.1186/1471-2105-15-S10-P7

来源: Springer

【 授权许可】

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© Li et al; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.