In vitro biological properties and health benefits of a novel sulfated polysaccharide isolated from Cymodocea nodosa

Lipids in Health and Disease

Research

Donyez Frikha¹  Bochra Gargouri²  Saloua Lassoued²  Rihab Ben Abdallah Kolsi³  Karima Belghith³  Sameh Sassi⁴ 

[1] Biodiversity Unit and aquatic ecosystems, Faculty of Sciences of Sfax, 3038, Sfax, Tunisia;Biotechnology Unit and Pathologies, Superior Institute of Biotechnology of Sfax, 3038, Sfax, Tunisia;Laboratory of Plant Biotechnology Applied to the Improvement of Cultures, Faculty of Sciences of Sfax, 3038, Sfax, Tunisia;Unité de Biodiversité et Valorisation des Bioressources en zones arides, Faculté des Sciences de Gabes, Gabes, Tunisia;

关键词: Polysaccharide;    GCMS;    DNA;    PCR;    Antioxidant;    Antimicrobial;    Cytotoxicity test;   

DOI  :  10.1186/s12944-017-0643-y

 received in 2017-10-05, accepted in 2017-12-11,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundDuring the last few decades, there has been a growing interest in the search for novel bioactive compounds from marine origins.MethodsThe present study is the first to determine the molecular characterization which it was deposited in the genebank database, to investigate and evaluate the biological properties of sulfated polysaccharide from Cymodocea nodosa (CNSP) seagrass.ResultsThe results revealed that CNSP had high activity in total antioxidant assay (59.03 mg ascorbic acid equivalents/g extract), reducing power (OD = 0.3), DPPH radical scavenging (IC50 = 1.22 mg/ml) and ABTS radical scavenging (IC50 = 1.14 mg/ml). It was also noted to exhibit antimicrobial activity against a wide range of microorganisms, with important inhibition zones. The results revealed that CNSP was able to inhibit the proliferation of Hela cell lines with a dose-dependent manner.ConclusionOverall, the results presented in this study demonstrate that CNSP has several attractive antioxidant, antimicrobial and antiproliferative properties with potential benefits towards health.

【 授权许可】

CC BY   
© The Author(s). 2017