Correction with blood T1 is essential when measuring post-contrast myocardial T1 value in patients with acute myocardial infarction

Journal of Cardiovascular Magnetic Resonance

Research

Chul Hwan Park¹  Tae Hoon Kim¹  Sung Ho Hwang¹  Byoung Kwon Lee²  Hyuck Moon Kwon²  Eui-Young Choi²  Ji-Hyun Yoon²  Pil-Ki Min²  Hyemoon Chung²  Jong-Youn Kim²  Bum-Kee Hong²  Young Won Yoon²  Se-Joong Rim²  Andreas Greiser³  Mun Young Paek⁴ 

[1] Department of Radiology Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea;Division of Cardiology, Heart Center, Gangnam Severance Hospital Yonsei University College of Medicine, Seoul, South Korea;Siemens AG Healthcare, Erlangen, Germany;Siemens Healthcare, Seoul, Republic of Korea;

关键词: Cardiovascular magnetic resonance;    T1 mapping;    Myocardium;   

DOI  :  10.1186/1532-429X-15-11

 received in 2012-07-14, accepted in 2012-12-17,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundPost-contrast T1 mapping by modified Look-Locker inversion recovery (MOLLI) sequence has been introduced as a promising means to assess an expansion of the extra-cellular space. However, T1 value in the myocardium can be affected by scanning time after bolus contrast injection. In this study, we investigated the changes of the T1 values according to multiple slicing over scanning time at 15 minutes after contrast injection and usefulness of blood T1 correction.MethodsEighteen reperfused acute myocardial infarction (AMI) patients, 13 cardiomyopathy patients and 8 healthy volunteers underwent cardiovascular magnetic resonance with 15 minute-post contrast MOLLI to generate T1 maps. In 10 cardiomyopathy cases, pre- and post-contrast MOLLI techniques were performed to generate extracellular volume fraction (Ve). Six slices of T1 maps according to the left ventricular (LV) short axis, from apex to base, were consecutively obtained. Each T1 value was measured in the whole myocardium, infarcted myocardium, non-infarcted myocardium and LV blood cavity.ResultsThe mean T1 value of infarcted myocardium was significantly lower than that of non-infarcted myocardium (425.4±68.1 ms vs. 540.5±88.0 ms, respectively, p< 0.001). T1 values of non-infarcted myocardium increased significantly from apex to base (from 523.1±99.5 ms to 561.1±81.1 ms, p=0.001), and were accompanied by a similar increase in blood T1 value in LV cavity (from 442.1±120.7 ms to 456.8±97.5 ms, p<0.001) over time. This phenomenon was applied to both left anterior descending (LAD) territory (from 545.1±74.5 ms to 575.7±84.0 ms, p<0.001) and non-LAD territory AMI cases (from 501.2±124.5 ms to 549.5±81.3 ms, p<0.001). It was similarly applied to cardiomyopathy patients and healthy volunteers. After the myocardial T1 values, however, were adjusted by the blood T1 values, they were consistent throughout the slices from apex to base (from 1.17±0.18 to 1.25±0.13, p>0.05). The Ve did not show significant differences from apical to basal slices.ConclusionPost-contrast myocardial T1 corrected by blood T1 or Ve, provide more stable measurement of degree of fibrosis in non-infarcted myocardium in short- axis multiple slicing.

【 授权许可】

CC BY   
© Choi et al.; licensee BioMed Central Ltd. 2013