Association of serum leptin levels with central arterial stiffness in coronary artery disease patients

BMC Cardiovascular Disorders

Research Article

Mei-Ling Chen¹  Chiu-Fen Yang¹  Yu-Chih Chen¹  Jen-Pi Tsai²  Ji-Hung Wang³  Bang-Gee Hsu⁴ 

[1] Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan;Division of Nephrology, Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan;School of Medicine, Tzu Chi University, Hualien, Taiwan;School of Medicine, Tzu Chi University, Hualien, Taiwan;Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan;School of Medicine, Tzu Chi University, Hualien, Taiwan;Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan;

关键词: Arterial stiffness;    Carotid-femoral pulse wave velocity;    Coronary artery disease;    Leptin;   

DOI  :  10.1186/s12872-016-0268-5

 received in 2015-09-25, accepted in 2016-04-29,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundSerum adipokines have roles in the development of arterial stiffness. Our aim was to investigate the relationship of leptin and the surrogate marker carotid-femoral pulse wave velocity (cfPWV) in coronary artery disease (CAD) patients.MethodsFasting blood samples were obtained from 105 CAD patients. cfPWV was measured with the SphygmoCor system. A cfPWV > 10 m/s was defined as high arterial stiffness, and ≤ 10 m/s as low arterial stiffness.ResultsThirty-seven patients (35.2 %) had high arterial stiffness, and had a higher percentage of diabetes (P = 0.001), hypertension (P = 0.010), older age (P = 0.001), and higher systolic blood pressure (SBP) (P < 0.001), diastolic blood pressure (DBP) (P = 0.021), pulse pressure (P = 0.014), and serum leptin level (P = 0.002) compared to patients with low arterial stiffness. Serum leptin levels correlated with the number of angiographically documented stenotic coronary artery vessels (P < 0.001). After adjusting for factors significantly associated with arterial stiffness, multivariate logistic regression analysis showed that leptin (odds ratio = 1.026, 95 % confidence interval: 1.002–1.051, P = 0.037) was a significant independent predictor of arterial stiffness.ConclusionsIncreasing serum concentration of leptin correlated positively with the total number of stenotic coronary arteries, and serum leptin level may predict the development of arterial stiffness in CAD patients.

【 授权许可】

CC BY   
© Tsai et al. 2016