Symptom profile in partial responders to a proton pump inhibitor compared with treatment-naïve patients with gastroesophageal reflux disease: a post hoc analysis of two study populations

BMC Gastroenterology

Research Article

Anna Rydén¹  Anna Niklasson¹  Hans Denison¹  Nimish Vakil² 

[1] AstraZeneca R&D, Mölndal, Sweden;University of Wisconsin School of Medicine and Public Health, Aurora Summit Hospital, 36500 Aurora Drive, 53066, Summit, WI, USA;

关键词: Abdominal pain;    Constipation;    Heartburn;    Proton pump inhibitors;    Regurgitation;    Gastric;   

DOI  :  10.1186/1471-230X-14-177

 received in 2014-05-01, accepted in 2014-07-28,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundPartial response to proton pump inhibitor (PPI) therapy poses a healthcare challenge. This study aimed to compare symptom profiles in partial PPI responders and treatment-naïve patients with gastroesophageal reflux disease (GERD).MethodsA post hoc analysis of data from two studies was performed. Partial PPI responders with GERD (n = 580; NCT00703534) had frequent (≥ 3 days/week) heartburn and/or regurgitation despite PPI therapy; patients with no improvement were excluded. Treatment-naïve patients with GERD (diagnosed by endoscopy and pH-metry; n = 203; NCT00291746) had frequent (≥ 3 days/week) upper gastrointestinal symptoms. The Gastrointestinal Symptom Rating Scale (GSRS) was completed by all patients at study entry and by treatment-naïve patients after PPI therapy.ResultsThe highest (mean [95% confidence interval]) discomfort scores were reported in the Reflux (heartburn, regurgitation), Indigestion, and Abdominal pain domains of the GSRS, both in partial PPI responders (4.3 [4.2–4.4], 3.7 [3.6–3.8], and 3.4 [3.3–3.5], respectively) and in treatment-naïve patients (3.5 [3.3–3.7], 3.6 [3.4–3.7], and 3.1 [3.0–3.3], respectively). Partial PPI responders reported more discomfort than treatment-naïve patients in the Reflux, Abdominal pain, and Constipation domains (4.3 [4.2–4.4] vs. 3.5 [3.3–3.7], 3.4 [3.3–3.5] vs. 3.1 [3.0–3.3], and 2.5 [2.4–2.6] vs. 2.1 [1.9–2.2], respectively). All GSRS domain scores improved in treatment-naïve patients following PPI therapy.ConclusionsSymptom patterns in partial PPI responders were similar to those in treatment-naïve patients with GERD, but partial PPI responders experienced more severe reflux, abdominal pain, and constipation than did treatment-naïve patients.

【 授权许可】

CC BY   
© Vakil et al.; licensee BioMed Central Ltd. 2014