Effect of fruit and vegetable concentrates on endothelial function in metabolic syndrome: A randomized controlled trial

Nutrition Journal

Research

Yuka Yazaki¹  Yingying Ma¹  David L Katz¹  Valentine Y Njike¹  Ather Ali¹ 

[1] Prevention Research Center, Yale University School of Medicine, Griffin Hospital, 130 Division Street, 2nd Floor, 06418, Derby, Connecticut, USA;

关键词: phytonutrients;    dietary supplements;    cardiovascular;    antioxidant;    randomized;    fruit;    vegetable;   

DOI  :  10.1186/1475-2891-10-72

 received in 2011-03-25, accepted in 2011-06-29,  发布年份 2011

来源: Springer

【 摘 要 】

Background and ObjectiveDehydrated fruit and vegetable concentrates provide an accessible form of phytonutrient supplementation that may offer cardioprotective effects. This study assessed the effects of two blends of encapsulated juice powder concentrates (with and without added berry powders) on endothelial function in persons with metabolic syndrome, a risk factor for type 2 diabetes and cardiovascular disease.MethodsRandomized, double blind, placebo controlled crossover clinical trial with three treatment arms. 64 adults with metabolic syndrome were enrolled and received 8-week sequences of each blend of the concentrates and placebo. The primary outcome measure was change in endothelial function (assessed as flow-mediated dilatation of the brachial artery) 2 hr after consuming a 75 g glucose load, after 8-weeks of daily consumption (sustained) or 2 hr after consumption of a single dose (acute). Secondary outcome measures included plasma glucose, serum insulin, serum lipids, and body weight.ResultsNo significant between-group differences in endothelial function with daily treatment for 8 weeks were seen. No other significant treatment effects were discerned in glucose, insulin, lipids, and weight.ConclusionEncapsulated fruit and vegetable juice powder concentrates did not alter insulin or glucose measures in this sample of adults with metabolic syndrome.Trial Registrationclinicaltrials.gov NCT01224743

【 授权许可】

Unknown   
© Ali et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.