Association of serum ferritin with non-alcoholic fatty liver disease: a meta-analysis

Lipids in Health and Disease

Research

Wen-wen Jin¹  Ning Geng¹  Li-Zhen Chen²  Cong Wang³  Hai-Yan Yue³  Lin-Lin Lu⁴  David W. Victor⁵  Shui-Xian Du⁶  Yong-Ning Xin⁷  Shi-Ying Xuan⁷ 

[1] Department of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozhou Road, 266011, Qingdao, Shandong Province, China;Department of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozhou Road, 266011, Qingdao, Shandong Province, China;College of Medicine and Pharmaceutics, Ocean University of China, 266003, Qingdao, China;Department of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozhou Road, 266011, Qingdao, Shandong Province, China;Department of Gastroenterology, Dalian Medical University, 266011, Qingdao, China;Digestive Disease Key Laboratory of Qingdao, 266071, Qingdao, China;Central Laboratories, Qingdao Municipal Hospital, 266071, Qingdao, China;Hepatology & Transplant Medicine, Department of Medicine, Houston Methodist Hospital, Houston, USA;Medical College of Qingdao University, 266071, Qingdao, China;Department of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozhou Road, 266011, Qingdao, Shandong Province, China;Medical College of Qingdao University, 266071, Qingdao, China;Department of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozhou Road, 266011, Qingdao, Shandong Province, China;Digestive Disease Key Laboratory of Qingdao, 266071, Qingdao, China;

关键词: Non-alcoholic fatty liver disease (NAFLD);    Meta-analysis;    Serum ferritin (SFL);    Non-alcoholic steatohepatitis (NASH);    Non-alcoholic fatty liver (NAFL);   

DOI  :  10.1186/s12944-017-0613-4

 received in 2017-04-18, accepted in 2017-11-12,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundA growing number of studies reported the connection between the level of serum ferritin (SFL) and non-alcoholic fatty liver disease (NAFLD). However, such connection was still disputable. The aim of our meta-analysis was to estimate SFL between the groups as below: patients with NAFLD against control group; non-alcoholic steatohepatitis (NASH) patients against control group; non-alcoholic fatty liver (NAFL) patients against a control group and NASH patients vs NAFL patients.MethodsWe screened the studies in PubMed, EMBASE, the Cochrane Database and the Cochrane Central register controlled trials from the beginning to July 10, 2016 to find the studies indicated the connection between SFL and NAFLD (NAFL and/or NASH). Fourteen published studies which evaluate the SFL in NAFLD patients were selected.ResultsHigher SFL was noticed in NAFLD patients against control group (standardized mean difference [SMD] 1.01; 95% CI 0.89, 1.13), NASH patients against control group (SMD 1.21; 95% CI 1.00, 1.42), NAFL patients against control group (SMD 0.51; 95% CI 0.24, 0.79) and NASH patients against NAFL patients (SMD 0.63; 95% CI 0.52, 0.75). These results remained unaltered actually after the elimination of studies which were focused on paediatric or adolescent populations. Higher SFL was presented in NAFLD patients against the control group (SMD 1.08; 95% CI 0.95, 1.20) in adults and NASH patients against NAFL patients in adults (SMD 0.74; 95% CI 0.62, 0.87). The connection between SFL and NASH against NAFL group in paediatric or adolescent populations was observed inconsistently (SMD 0.10; 95% CI -0.18, 0.38).ConclusionsThe level of SFL was elevated in patients with NAFLD (NAFL and/or NASH) compared with the controls. Compared with NAFL, The level of SFL was increased in NASH. The result remained unaltered actually after the elimination of studies focused on paediatric or adolescent populations.

【 授权许可】

CC BY   
© The Author(s). 2017