Vertebrate Hedgehog signaling: cilia rule

BMC Biology

Commentary

Didier YR Stainier¹  Christopher W Wilson² 

[1] Department of Biochemistry and Biophysics, Program in Developmental and Stem Cell Biology, the Liver Center, Cardiovascular Research Institute and Diabetes Center, University of California, 94158, San Francisco, CA, USA;Tumour Biology and Angiogenesis Department, Genentech Inc., 1 DNA Way, 94080, South San Francisco, CA, USA;

关键词: Basal Body;    Primary Cilium;    Dynein Motor;    Intraflagellar Transport;    Cilium Formation;   

DOI  :  10.1186/1741-7007-8-102

 received in 2010-05-14, accepted in 2010-07-26,  发布年份 2010

来源: Springer

【 摘 要 】

The Hedgehog (Hh) signaling pathway differentially utilizes the primary cilium in mammals and fruit flies. Recent work, including a study in BMC Biology, demonstrates that Hh signals through the cilium in zebrafish, clarifying the evolution of Hh signal transduction.See research article: http://www.biomedcentral.com/1741-7007/8/65

【 授权许可】

CC BY   
© Wilson and Stainier; licensee BioMed Central Ltd. 2010