Traffic air pollution and mortality from cardiovascular disease and all causes: a Danish cohort study

Environmental Health

Research

Johnni Hansen¹  Mette Sørensen¹  Anne Tjønneland¹  Ole Raaschou-Nielsen¹  Zorana Jovanovic Andersen²  Steen Solvang Jensen³  Matthias Ketzel³  Kim Overvad⁴  Steffen Loft⁵ 

[1] Danish Cancer Society Research Center, Copenhagen, Denmark;Danish Cancer Society Research Center, Copenhagen, Denmark;Department of Public Health, Center for Epidemiology and Screening, University of Copenhagen, Copenhagen, Denmark;Department of Environmental Science, Aarhus University, Roskilde, Denmark;Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark;Department of Public Health, Section of Environmental Health, University of Copenhagen, Copenhagen, Denmark;

关键词: Traffic;    Air pollution;    Cardiovascular mortality;    Total mortality;    Cohort;   

DOI  :  10.1186/1476-069X-11-60

 received in 2012-03-30, accepted in 2012-08-28,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundTraffic air pollution has been linked to cardiovascular mortality, which might be due to co-exposure to road traffic noise. Further, personal and lifestyle characteristics might modify any association.MethodsWe followed up 52 061 participants in a Danish cohort for mortality in the nationwide Register of Causes of Death, from enrollment in 1993–1997 through 2009, and traced their residential addresses from 1971 onwards in the Central Population Registry. We used dispersion-modelled concentration of nitrogen dioxide (NO2) since 1971 as indicator of traffic air pollution and used Cox regression models to estimate mortality rate ratios (MRRs) with adjustment for potential confounders.ResultsMean levels of NO2 at the residence since 1971 were significantly associated with mortality from cardiovascular disease (MRR, 1.26; 95% confidence interval [CI], 1.06–1.51, per doubling of NO2 concentration) and all causes (MRR, 1.13; 95% CI, 1.04–1.23, per doubling of NO2 concentration) after adjustment for potential confounders. For participants who ate < 200 g of fruit and vegetables per day, the MRR was 1.45 (95% CI, 1.13–1.87) for mortality from cardiovascular disease and 1.25 (95% CI, 1.11–1.42) for mortality from all causes.ConclusionsTraffic air pollution is associated with mortality from cardiovascular diseases and all causes, after adjustment for traffic noise. The association was strongest for people with a low fruit and vegetable intake.

【 授权许可】

CC BY   
© Raaschou-Nielsen et al.; licensee BioMed Central Ltd. 2012