期刊论文详细信息
Environmental Health
Maternal exposure to metals and persistent pollutants and cord blood immune system biomarkers
Research
Adrian R. Levy1  Robert W Platt2  Jean S Marshall3  Linda Dodds4  Jillian Ashley-Martin5  Tye E. Arbuckle6 
[1] Department of Community Health & Epidemiology, Dalhousie University, Centre for Clinical Research, 5790 University Avenue, B3H 1 V7, Halifax, NS, Canada;Department of Epidemiology and Biostatistics, McGill University, Purvis Hall 1020 Pine Ave. West, H3A 1A2, Montreal, QC, Canada;Department of Microbiology & Immunology, Dalhousie University Sir Charles Tupper Medical Building, Room 7-C5850 College Street, Halifax, NS, Canada;Department of Obstetrics & Gynaecology and Paediatrics, Dalhousie University, Perinatal Epidemiology Research Unit, PO Box 9700, 7th Floor Women’s Site, IWK Health Centre, 5980 University Ave, B3H 6R8, Halifax, NS, Canada;Interdisciplinary PhD Program, Dalhousie University, IDPhD c/o Faculty of Graduate Studies Room 314 Henry Hicks Building 6299 South St Halifax, B3H 4H6, Halifax, NS, Canada;Population Studies Division, Healthy Environments and Consumer Safety Branch, Health Canada, 50 Colombine Dr., AL 0801A, K1A 0 K9, Ottawa, ON, Canada;
关键词: Persistent organic pollutants;    Metals;    Pesticides;    Immunoglobulin E;    Thymic stromal lymphopoietin;    Interleukin-33;    Pregnancy;    Cohort;   
DOI  :  10.1186/s12940-015-0046-3
 received in 2015-04-02, accepted in 2015-06-08,  发布年份 2015
来源: Springer
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【 摘 要 】

BackgroundThe fetal time period is a critical window of immune system development and resulting heightened susceptibility to the adverse effects of environmental exposures. Epidemiologists and toxicologists have hypothesized that persistent organic pollutants, pesticides and metals have immunotoxic properties. Immunotoxic effects may manifest as an altered immune system profile at birth. Immunoglobulin E, thymic stromal lymphopoietin (TSLP), and interleukin-33 (IL-33) may be implicated in the etiology of childhood allergy and are detectable at birth. The objective of this study was to examine the potential relationship between maternal concentrations of metals, persistent organic pollutants, and pesticides and elevated umbilical cord blood concentrations of IgE, TSLP, and IL-33 in a Canadian birth cohort.MethodsThis study utilized data collected in the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a trans-Canada cohort study of 2,001 pregnant women. Of these women, 1258 had a singleton, term birth and cord blood sample. Logistic regression was used to determine associations between log-transformed continuous variables and immune system biomarkers.ResultsInverse relationships were observed between lead, DDE, PCB-118, and a summary index of organophosphorous metabolites and jointly elevated concentrations of IL-33 and TSLP. None of the environmental contaminants were associated with increased odds of a high cord blood immune system biomarker concentration.ConclusionsIn this primarily urban Canadian population of pregnant women and their newborns, maternal blood or urine concentrations of persistent organic pollutants, pesticides, and metals were not associated with immunotoxic effects that manifest as increased odds of elevated concentrations of IgE, TSLP or IL-33.

【 授权许可】

Unknown   
© Ashley-Martin et al. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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