Gene expression profiling reveals distinct features of various porcine adipose tissues

Lipids in Health and Disease

Research

Miaomiao Mai¹  Li Zhu¹  Jideng Ma¹  Jie Zhang¹  Lin Bai¹  Guoqing Tang¹  Anan Jiang¹  Chaowei Zhou¹  Mingzhou Li¹  Xuewei Li¹ 

[1] Institute of Animal Genetics & Breeding, College of Animal Science & Technology, Sichuan Agricultural University, 625000, Ya’an, Sichuan, China;

关键词: Gene expression profiling;    Subcutaneous adipose tissues;    Visceral adipose tissues;    Pig;   

DOI  :  10.1186/1476-511X-12-75

 received in 2013-03-14, accepted in 2013-05-22,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundThe excessive accumulation of body fat is a major risk factor to develop a variety of metabolic diseases. To investigate the systematic association between the differences in gene expression profiling and adipose deposition, we used pig as a model, and measured the gene expression profiling of six variant adipose tissues in male and females from three pig breeds which display distinct fat level.ResultsWe identified various differential expressed genes among breeds, tissues and between sexes, and further used a clustering method to identify sets of functionally co-expression genes linked to different obesity-related phenotypes. Our results reveal that the subcutaneous adipose tissues mainly modulate metabolic indicators, nonetheless, the visceral adipose tissues as well as the intermuscular adipose tissue were mainly associated with the impaired inflammatory and immune response.ConclusionsThe present study provided the evidence of gene expression profiling that the subcutaneous adipose tissues are mainly affected the metabolism process, whereas the visceral and intermuscular adipose tissues should been term as the metabolic risk factors of obesity.

【 授权许可】

Unknown   
© Zhou et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.