Gene expression profiling reveals distinct features of various porcine adipose tissues

Lipids in Health and Disease

Xuewei Li¹  Mingzhou Li¹  Lin Bai¹  Li Zhu¹  Miaomiao Mai¹  Guoqing Tang¹  Anan Jiang¹  Jideng Ma¹  Jie Zhang¹  Chaowei Zhou¹ 

[1] Institute of Animal Genetics & Breeding, College of Animal Science & Technology, Sichuan Agricultural University, Ya’an, Sichuan, 625000, China

关键词: Pig;    Visceral adipose tissues;    Subcutaneous adipose tissues;    Gene expression profiling;   

Others  :  834629
DOI  :  10.1186/1476-511X-12-75

 received in 2013-03-14, accepted in 2013-05-22,  发布年份 2013

【 摘 要 】

Background

The excessive accumulation of body fat is a major risk factor to develop a variety of metabolic diseases. To investigate the systematic association between the differences in gene expression profiling and adipose deposition, we used pig as a model, and measured the gene expression profiling of six variant adipose tissues in male and females from three pig breeds which display distinct fat level.

Results

We identified various differential expressed genes among breeds, tissues and between sexes, and further used a clustering method to identify sets of functionally co-expression genes linked to different obesity-related phenotypes. Our results reveal that the subcutaneous adipose tissues mainly modulate metabolic indicators, nonetheless, the visceral adipose tissues as well as the intermuscular adipose tissue were mainly associated with the impaired inflammatory and immune response.

Conclusions

The present study provided the evidence of gene expression profiling that the subcutaneous adipose tissues are mainly affected the metabolism process, whereas the visceral and intermuscular adipose tissues should been term as the metabolic risk factors of obesity.

【 授权许可】

   
2013 Zhou et al.; licensee BioMed Central Ltd.

【 图 表 】

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