Cut off values for abdominal obesity as a criterion of metabolic syndrome in an ethnic Kyrgyz population (Central Asian region)

Cardiovascular Diabetology

Original Investigation

Cholpon B Moldokeeva¹  Alina S Kerimkulova¹  Malik P Nabiev¹  Aibek E Mirrakhimov²  Erkin M Mirrakhimov²  Olga S Lunegova³ 

[1] Kyrgyz State Medical Academy named by I.K. Akhunbaev, Akhunbaev street 92, 720020, Bishkek, Kyrgyzstan;Kyrgyz State Medical Academy named by I.K. Akhunbaev, Akhunbaev street 92, 720020, Bishkek, Kyrgyzstan;National Centre of Cardiology and Internal medicine named by M. Mirrakhimov, T. Moldo 3, 720040, Bishkek, Kyrgyzstan;National Centre of Cardiology and Internal medicine named by M. Mirrakhimov, T. Moldo 3, 720040, Bishkek, Kyrgyzstan;

关键词: Obesity;    Abdominal obesity;    Waist circumference insulin resistance;    Metabolic syndrome;    Cardiovascular risk;   

DOI  :  10.1186/1475-2840-11-16

 received in 2011-12-05, accepted in 2012-02-22,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundPeople of different racial and ethnic backgrounds have a distinct pattern of central fat deposition, thus making it necessary to devise a race based approach for the diagnosis and evaluation of abdominal obesity (AO). This is the first study to determine the optimal waist circumference (WC) cutoff values for definition of AO in an ethnic Kyrgyz population.Methods323 persons of Kyrgyz ethnicity (183 women and 140 men), with a mean age of 51.8 ± 9.5 years old were included in the study. Measurement of blood pressure (BP), anthropometric data (including body mass index calculation and WC measurement), fasting blood sugar, serum lipid parameters and insulin were performed in all examined individuals. Insulin resistance (IR) was considered as HOMA index (insulin × fasting glucose/22.5) ≥ 2.77. Sensitivity and specificity for the presence of IR or two other criteria of MS (according to the international classification, 2009) were calculated by using receiver operating characteristic (ROC) curves for men and women separately.ResultsThe optimal sensitivity and specificity obtained from the ROC curves for IR were 88 cm in women (sensitivity of 0.85, 95%CI (0.72-0.93), specificity of 0.58, 95%CI (0.49-0.66)) and 94 cm for men (sensitivity of 0.8, 95% CI (0.65-0.91), specificity of 0.61, 95% CI (0.51-0.71)). The data from the ROC curve for any two other MS criteria confirmed the results and the WC 88 cm in women (sensitivity of 0.82, 95% CI (0.72-0.9), specificity of 0.72, 95% CI (0.62-0.8)) and 94 cm in men (sensitivity of 0.74, 95% CI (0.62-0.84), specificity of 0.73, 95% CI (0.61-0.83)) were corresponded to the optimal sensitivity and specificity.ConclusionWC ≥ 88 cm and ≥ 94 cm should be used as a criterion for the diagnosis of AO for Kyrgyz women and men respectively based on these results.

【 授权许可】

CC BY   
© Mirrakhimov et al; licensee BioMed Central Ltd. 2012