Haptoglobin genotype predicts development of coronary artery calcification in a prospective cohort of patients with type 1 diabetes

Cardiovascular Diabetology

Original Investigation

Gregory L Kinney¹  Melissa Simpson¹  Janet K Snell-Bergeon¹  Marian J Rewers¹  Andrew P Levy²  Yefim Anbinder²  Orit Lache²  Rachel Miller-Lotan² 

[1] Barbara Davis Center for Childhood Diabetes, Aurora, CO, USA;Technion Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel;

关键词: Cardiovascular disease;    type 1 diabetes mellitus;    coronary artery calcium;    hyperglycemia;    genetics;    Haptoglobin;   

DOI  :  10.1186/1475-2840-10-99

 received in 2011-10-04, accepted in 2011-11-20,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundCoronary artery disease has been linked with genotypes for haptoglobin (Hp) which modulates extracorpuscular hemoglobin. We hypothesized that the Hp genotype would predict progression of coronary artery calcification (CAC), a marker of subclinical atherosclerosis.MethodsCAC was measured three times in six years among 436 subjects with type 1 diabetes and 526 control subjects participating in the Coronary Artery Calcification in Type 1 Diabetes (CACTI) study. Hp typing was performed on plasma samples by polyacrylamide gel electrophoresis.ResultsThe Hp 2-2 genotype predicted development of significant CAC only in subjects with diabetes who were free of CAC at baseline (OR: 1.95, 95% CI: 1.07-3.56, p = 0.03), compared to those without the Hp 2-2 genotype, controlling for age, sex, blood pressure and HDL-cholesterol. Hp 2 appeared to have an allele-dose effect on development of CAC. Hp genotype did not predict CAC progression in individuals without diabetes.ConclusionsHp genotype may aid prediction of accelerated coronary atherosclerosis in subjects with type 1 diabetes.

【 授权许可】

Unknown   
© Simpson et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.