G6PD deficiency in Plasmodium falciparum and Plasmodium vivax malaria-infected Cambodian patients

Malaria Journal

Research

Benoit Witkowski¹  Pheaktra Chim¹  Christophe Benedet¹  Nimol Khim¹  Lydie Canier¹  Didier Ménard¹  Saorin Kim¹  Pety Tor²  Alexandra Kerleguer²  Rithea Leang³  Sovannaroth Siv³  Socheat Duong³  Sim Kheng³  Walter RJ Taylor³  Soley Lek³  Char Meng Chuor³  Sinuon Muth³  Nguon Chea³ 

[1] Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia;Medical Laboratory, Institut Pasteur du Cambodge, Phnom Penh, Cambodia;National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia;

关键词: Malaria;    Vivax Malaria;    Malaria Patient;    Primaquine;    Artemisinin Resistance;   

DOI  :  10.1186/1475-2875-12-171

 received in 2013-03-15, accepted in 2013-05-24,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundGlucose-6-phosphate-dehydrogenase deficiency (G6PDd) rates are unknown in malaria-infected Cambodian patients. These data are key to a rational drug policy for malaria elimination of Plasmodium falciparum and Plasmodium vivax.MethodsFrom September 2010–2012, a two-year survey of G6PDd and haemoglobinopathies assessed by quantitative enzyme activity assay and haemoglobin electrophoresis, respectively, was conducted in malaria-infected patients presenting to 19 health centres throughout Cambodia.ResultsA total of 2,408 confirmed malaria patients of mean age 26.7 (range 2–81) years were recruited from mostly western Cambodia (n = 1,732, 71.9%); males outnumbered females by 3.9:1. Plasmodium falciparum was present in 1,443 (59.9%) and P. vivax in 965 (40.1%) patients. Mean G6PD activity was 11.6 (CI 95%: 11.4-11.8) U/g Hb, G6PDd was present in 13.9% of all patients (335/2,408) and severe G6PDd (including WHO Class I and II variants) was more common in western (158/1,732, 9.1%) versus eastern (21/414, 5.1%) Cambodia (P = 0.01). Of 997/2,408 (41.4%) had a haemoglobinopathy. Mean haemoglobin concentrations were inversely related to age: 8.1 g/dL < five years, 8.7 g/dL five to 14 years, and 10.4 g/dL >15 years (P <0.001).ConclusionsG6PDd prevalence, anaemia and haemoglobinopathies were common in malaria-infected patients. The deployment of primaquine in Cambodia should be preceded by primaquine safety studies paralleled with evaluations of easy to use tests to detect G6PDd.

【 授权许可】

Unknown   
© Khim et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.