Daily intake of antioxidants in relation to survival among adult patients diagnosed with malignant glioma

BMC Cancer

Research Article

Dora Il'yasova¹  Lucie McCoy²  Terri Rice²  Margaret Wrensch²  Charles P Quesenberry³  Ai-Lin Tsai³  Gerald N DeLorenze³ 

[1] Department of Community and Family Medicine, Duke University Medical Center, 2424 Erwin Rd, Durham, NC, USA;Department of Neurological Surgery, University of California San Francisco, 44 Page St, San Francisco, USA;Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA, USA;

关键词: Genistein;    Lycopene;    Malignant Glioma;    Glioma Patient;    Lower Tertile;   

DOI  :  10.1186/1471-2407-10-215

 received in 2009-08-29, accepted in 2010-05-19,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundMalignant glioma is a rare cancer with poor survival. The influence of diet and antioxidant intake on glioma survival is not well understood. The current study examines the association between antioxidant intake and survival after glioma diagnosis.MethodsAdult patients diagnosed with malignant glioma during 1991-1994 and 1997-2001 were enrolled in a population-based study. Diagnosis was confirmed by review of pathology specimens. A modified food-frequency questionnaire interview was completed by each glioma patient or a designated proxy. Intake of each food item was converted to grams consumed/day. From this nutrient database, 16 antioxidants, calcium, a total antioxidant index and 3 macronutrients were available for survival analysis. Cox regression estimated mortality hazard ratios associated with each nutrient and the antioxidant index adjusting for potential confounders. Nutrient values were categorized into tertiles. Models were stratified by histology (Grades II, III, and IV) and conducted for all (including proxy) subjects and for a subset of self-reported subjects.ResultsGeometric mean values for 11 fat-soluble and 6 water-soluble individual antioxidants, antioxidant index and 3 macronutrients were virtually the same when comparing all cases (n = 748) to self-reported cases only (n = 450). For patients diagnosed with Grade II and Grade III histology, moderate (915.8-2118.3 mcg) intake of fat-soluble lycopene was associated with poorer survival when compared to low intake (0.0-914.8 mcg), for self-reported cases only. High intake of vitamin E and moderate/high intake of secoisolariciresinol among Grade III patients indicated greater survival for all cases. In Grade IV patients, moderate/high intake of cryptoxanthin and high intake of secoisolariciresinol were associated with poorer survival among all cases. Among Grade II patients, moderate intake of water-soluble folate was associated with greater survival for all cases; high intake of vitamin C and genistein and the highest level of the antioxidant index were associated with poorer survival for all cases.ConclusionsThe associations observed in our study suggest that the influence of some antioxidants on survival following a diagnosis of malignant glioma are inconsistent and vary by histology group. Further research in a large sample of glioma patients is needed to confirm/refute our results.

【 授权许可】

CC BY   
© DeLorenze et al; licensee BioMed Central Ltd. 2010