Health-related quality of life in glioma patients in China

BMC Cancer

Research Article

Rui Wang¹  Bo-lin Liu²  Wei-ping Liu²  Jin-xiang Cheng²  Xiang Zhang²  Hong Lin²  Wei Lin²  Jian-ning Zhang²  Yong-qiang Zhang²  Hong Yin³ 

[1] Department of Health Statistics, Fourth Military Medical University, Xi'an, Shaanxi Province, China;Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China;Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China;

关键词: Global Health;    Karnofsky Performance Status;    Glioma Patient;    Brain Tumor Patient;    Appetite Loss;   

DOI  :  10.1186/1471-2407-10-305

 received in 2009-08-20, accepted in 2010-06-18,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundHealth-related quality of life (HRQOL) has been increasingly emphasized in cancer patients. There are no reports comparing baseline HRQOL of different subgroups of glioma patients prior to surgery.MethodsHRQOL assessments by the standard Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30, version 3.0), the Mini-Mental State Examination and Karnofsky Performance Status were obtained from glioma patients prior to surgery.ResultsNinety-two pathologically confirmed glioma patients were recruited. There were 84.8% patients with emotional impairment, 75% with social and cognitive impairment, 70.7% with physical impairment, and 50% with role impairment. Eighty-two percent of patients reported fatigue symptoms, 72.8% reported pain, 50% reported appetite loss, 39.1% reported insomnia, and 36.9% reported nausea/vomiting, whereas other symptoms (dyspnea, diarrhea, constipation) in the QLQ-C30 were reported by fewer than 30% of patients. Fatigue and pain symptoms and all "functioning" scales were strongly correlated with global health status/quality of life (QoL). Fatigue was strongly related to all functioning scales, pain, appetite loss, and global health status/QoL. No difference in baseline HRQOL prior to surgery was reported between females and males, among different lesion locations, or between normal- and abnormal-cognition subgroups of glioma patients. Age, KPS, WHO grade, and tumor recurrence significantly affected HRQOL in glioma patients.ConclusionsThese data provided the baseline HRQOL in glioma patients prior to surgery in China. Most pre-surgery glioma patients indicated emotional, social, cognitive, physical, and role impairment. Fatigue, pain, appetite loss, insomnia, and nausea/vomiting were common in these patients. The fatigue and pain symptoms and all types of functioning strongly affected global health status/QoL. Old age, worse performance status, WHO grade IV and tumor recurrence had deleterious effects on HRQOL.

【 授权许可】

Unknown   
© Cheng et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.