No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations

BMC Medical Genetics

Research Article

Kentaro Matsuura¹  Yasuhito Tanaka¹  Yoichi Hiasa²  Masao Honda³  Shuichi Kaneko³  Masaaki Watanabe⁴  Katsushi Tokunaga⁵  Megumi Yamaoka⁵  Hiromi Sawai⁵  Nao Nishida⁶  Shuhei Hige⁷  Jong-Hon Kang⁸  Sang Hoon Ahn⁹  Jun Yong Park⁹  Kwang-Hyub Han⁹  Eiji Tanaka^1,10  Man-Fung Yuen^1,11  Satoshi Mochida^1,12  Namiki Izumi^1,13  Masayuki Kurosaki^1,13  Yasuhiro Asahina^1,13  Tatsuya Ide^1,14  Masaaki Korenaga^1,15  Keisuke Hino^1,15  Koichi Abe^1,16  Koichi Matsuda^1,17  Yusuke Nakamura^1,17  Hamdi Mbarek^1,17  Yoshito Itoh^1,18  Eiji Mita^1,19  Yoshikazu Murawaki^2,20  Masaya Sugiyama^2,21  Kiyoaki Ito^2,21  Masashi Mizokami^2,21  Yoriko Mawatari^2,21 

[1] Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan;Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan;Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan;Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan;Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, 113-0033, Bunkyo-ku, Tokyo, Japan;Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, 113-0033, Bunkyo-ku, Tokyo, Japan;The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan;Department of Internal Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan;Department of Internal Medicine, Teine Keijinkai Hospital, Sapporo, Japan;Department of International Medicine, Yonsei University College of Medicine, Seoul, South Korea;Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan;Department of Medicine, the University of Hong Kong, Queen Mary Hospital, Hong Kong, China;Division of Gastroenterology and Hepatology, Internal Medicine, Saitama Medical University, Saitama, Japan;Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan;Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan;Division of Hepatology and Pancreatology, Kawasaki Medical College, Kurashiki, Japan;First Department of Internal Medicine, Iwate Medical University, Iwate, Japan;Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan;Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan;National Hospital Organization Osaka National Hospital, Osaka, Japan;Second department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan;The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan;

关键词: Hepatitis B;    hepatocellular carcinoma;    candidate SNP;    replication study;    genome-wide association study;   

DOI  :  10.1186/1471-2350-13-47

 received in 2012-03-02, accepted in 2012-06-19,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundA recent genome-wide association study (GWAS) using chronic HBV (hepatitis B virus) carriers with and without hepatocellular carcinoma (HCC) in five independent Chinese populations found that one SNP (rs17401966) in KIF1B was associated with susceptibility to HCC. In the present study, a total of 580 HBV-derived HCC cases and 1351 individuals with chronic hepatitis B (CHB) or asymptomatic carrier (ASC) were used for replication studies in order to evaluate the reported association with HBV-derived HCC in other East Asian populations.ResultsWe did not detect any associations between rs17401966 and HCC in the Japanese cohorts (replication 1: OR = 1.09, 95 % CI = 0.82-1.43; replication 2: OR = 0.79, 95 % CI = 0.54-1.15), in the Korean cohort (replication 3: OR = 0.95, 95 % CI = 0.66-1.36), or in the Hong Kong Chinese cohort (replication 4: OR = 1.17, 95 % CI = 0.79-1.75). Meta-analysis using these cohorts also did not show any associations with P = 0.97.ConclusionsNone of the replication cohorts showed associations between rs17401966 and HBV-derived HCC. This may be due to differences in the genetic diversity among the Japanese, Korean and Chinese populations. Other reasons could be the high complexity of multivariate interactions between the genomic information and the phenotype that is manifesting. A much wider range of investigations is needed in order to elucidate the differences in HCC susceptibility among these Asian populations.

【 授权许可】

CC BY   
© Sawai et al.; licensee BioMed Central Ltd. 2012