No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations

BMC Medical Genetics

Katsushi Tokunaga⁷  Masashi Mizokami^1,17  Yasuhito Tanaka^2,20  Yusuke Nakamura⁸  Man-Fung Yuen³  Jun Yong Park^1,11  Kwang-Hyub Han^1,11  Sang Hoon Ahn^1,11  Masaya Sugiyama^1,17  Kiyoaki Ito^1,17  Tatsuya Ide^1,15  Yoichi Hiasa⁶  Yoshikazu Murawaki^1,13  Keisuke Hino^1,18  Masaaki Korenaga^1,18  Eiji Mita^1,12  Yoshito Itoh⁴  Kentaro Matsuura^2,20  Eiji Tanaka⁵  Shuichi Kaneko^1,19  Masao Honda^1,19  Namiki Izumi^1,16  Yasuhiro Asahina^1,16  Masayuki Kurosaki^1,16  Masaaki Watanabe¹  Satoshi Mochida²  Koichi Abe⁹  Jong-Hon Kang^1,10  Shuhei Hige^1,14  Megumi Yamaoka⁷  Yoriko Mawatari^1,17  Koichi Matsuda⁸  Hamdi Mbarek⁸  Nao Nishida^1,17  Hiromi Sawai⁷ 

[1] Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan;Division of Gastroenterology and Hepatology, Internal Medicine, Saitama Medical University, Saitama, Japan;Department of Medicine, the University of Hong Kong, Queen Mary Hospital, Hong Kong, China;Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan;Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan;Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan;Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan;Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan;First Department of Internal Medicine, Iwate Medical University, Iwate, Japan;Department of Internal Medicine, Teine Keijinkai Hospital, Sapporo, Japan;Department of International Medicine, Yonsei University College of Medicine, Seoul, Korea;National Hospital Organization Osaka National Hospital, Osaka, Japan;Second department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan;Department of Internal Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan;Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan;Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan;The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan;Division of Hepatology and Pancreatology, Kawasaki Medical College, Kurashiki, Japan;Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan;Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan

关键词: genome-wide association study;    replication study;    candidate SNP;    hepatocellular carcinoma;    Hepatitis B;   

Others  :  1177847
DOI  :  10.1186/1471-2350-13-47

 received in 2012-03-02, accepted in 2012-06-19,  发布年份 2012

【 摘 要 】

Background

A recent genome-wide association study (GWAS) using chronic HBV (hepatitis B virus) carriers with and without hepatocellular carcinoma (HCC) in five independent Chinese populations found that one SNP (rs17401966) in KIF1B was associated with susceptibility to HCC. In the present study, a total of 580 HBV-derived HCC cases and 1351 individuals with chronic hepatitis B (CHB) or asymptomatic carrier (ASC) were used for replication studies in order to evaluate the reported association with HBV-derived HCC in other East Asian populations.

Results

We did not detect any associations between rs17401966 and HCC in the Japanese cohorts (replication 1: OR = 1.09, 95 % CI = 0.82-1.43; replication 2: OR = 0.79, 95 % CI = 0.54-1.15), in the Korean cohort (replication 3: OR = 0.95, 95 % CI = 0.66-1.36), or in the Hong Kong Chinese cohort (replication 4: OR = 1.17, 95 % CI = 0.79-1.75). Meta-analysis using these cohorts also did not show any associations with P = 0.97.

Conclusions

None of the replication cohorts showed associations between rs17401966 and HBV-derived HCC. This may be due to differences in the genetic diversity among the Japanese, Korean and Chinese populations. Other reasons could be the high complexity of multivariate interactions between the genomic information and the phenotype that is manifesting. A much wider range of investigations is needed in order to elucidate the differences in HCC susceptibility among these Asian populations.

【 授权许可】

   
2012 Sawai et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Parkin DM, Bray F, Ferlay J, Pisani P: Global cancer statistics, 2002. CA: a cancer journal for clinicians 2005, 55(2):74-108.
• [2]Parkin DM: Global cancer statistics in the year 2000. The lancet oncology 2001, 2(9):533-543.
• [3]Marrero CR, Marrero JA: Viral hepatitis and hepatocellular carcinoma. Archives of medical research 2007, 38(6):612-620.
• [4]Kamatani Y, Wattanapokayakit S, Ochi H, Kawaguchi T, Takahashi A, Hosono N, Kubo M, Tsunoda T, Kamatani N, Kumada H, et al.: A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nature genetics 2009, 41(5):591-595.
• [5]Zhang H, Zhai Y, Hu Z, Wu C, Qian J, Jia W, Ma F, Huang W, Yu L, Yue W, et al.: Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nature genetics 2010, 42(9):755-758.
• [6]Abdulla MA, Ahmed I, Assawamakin A, Bhak J, Brahmachari SK, Calacal GC, Chaurasia A, Chen CH, Chen J, Chen YT, et al.: Mapping human genetic diversity in Asia. Science (New York, NY 2009, 326(5959):1541-1545.
• [7]Chan KY, Wong CM, Kwan JS, Lee JM, Cheung KW, Yuen MF, Lai CL, Poon RT, Sham PC, Ng IO: Genome-wide association study of hepatocellular carcinoma in Southern Chinese patients with chronic hepatitis B virus infection. PLoS One 2011, 6(12):e28798.
• [8]Sherman M: Hepatocellular carcinoma: epidemiology, surveillance, and diagnosis. Semin Liver Dis 2010, 30(1):3-16.
• [9]Yang HI, Yeh SH, Chen PJ, Iloeje UH, Jen CL, Su J, Wang LY, Lu SN, You SL, Chen DS, et al.: Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma. J Natl Cancer Inst 2008, 100(16):1134-1143.
• [10]Qian GS, Ross RK, Yu MC, Yuan JM, Gao YT, Henderson BE, Wogan GN, Groopman JD: A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China. Cancer Epidemiol Biomarkers Prev 1994, 3(1):3-10.
• [11]Ross RK, Yuan JM, Yu MC, Wogan GN, Qian GS, Tu JT, Groopman JD, Gao YT, Henderson BE: Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma. Lancet 1992, 339(8799):943-946.
• [12]Wang LY, Hatch M, Chen CJ, Levin B, You SL, Lu SN, Wu MH, Wu WP, Wang LW, Wang Q, et al.: Aflatoxin exposure and risk of hepatocellular carcinoma in Taiwan. International journal of cancer 1996, 67(5):620-625.
• [13]Liu Y, Wu F: Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Environmental health perspectives 2010, 118(6):818-824.
• [14]Nakamura Y: The BioBank Japan Project. Clin Adv Hematol Oncol 2007, 5(9):696-697.
• [15]Ohnishi Y, Tanaka T, Ozaki K, Yamada R, Suzuki H, Nakamura Y: A high-throughput SNP typing system for genome-wide association studies. Journal of human genetics 2001, 46(8):471-477.