Colonic medullary carcinoma: an exceedingly rare type of colorectal malignancy:a case report and review of the literature

Journal of Medical Case Reports

Case Report

Ali Toffaha¹  Mahmood Al-Dhaheri¹  Salwa Awad¹  Mohamed Kurer¹  Mohamed AbuNada¹  Fajer Al-Ishaq¹  Syed Rizvi² 

[1] Colorectal Surgery Unit, Hamad Medical Corporation, Doha, Qatar;Laboratory and Pathology Department, Hamad Medical Corporation, Doha, Qatar;

关键词: Colon cancer;    Medullary carcinoma;    Microsatellite instability;    Immunohistochemistry;   

DOI  :  10.1186/s13256-023-04160-0

 received in 2023-07-13, accepted in 2023-09-01,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundMedullary carcinoma of the colon is a rare subtype of colorectal cancer that has a unique, and sometimes varied, clinical and histologic profile. It usually presents in adult patients older than 50 years. Here, we report a unique case of young male patient who initially presented with abdominal pain followed by a large bowel obstruction.Case presentationA 40-year-old SriLankan male presented with right-sided abdominal pain and on examination, there was a palpable right iliac fossa mass. Colonoscopy and a computed tomography scan revealed cecal mass. Later, while waiting for elective resection, the patient developed symptoms and signs of a large bowel obstruction. He underwent a laparoscopic right hemicolectomy with an uneventful postoperative course. The histopathologic evaluation of the resected specimens showed invasive carcinoma with syncytial growth pattern, foci of lymphoid host response, and dirty necrosis, in keeping with a medullary carcinoma pT4a pN2b. Unlike most reported medullary carcinoma cases, this patient was young and caudal-related homeobox transcription factor 2 positive.ConclusionWe have reported another case of medullary carcinoma of the colon in a young patient with unique histologic characteristics. Reporting such cases helps in refine understanding of the histologic and genetic, as well as clinical, phenotypes of medullary carcinoma of the colon.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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