Electrochemotherapy with cisplatin enhances local control after surgical ablation of fibrosarcoma in cats: an approach to improve the therapeutic index of highly toxic chemotherapy drugs

Journal of Translational Medicine

Research

Francesca Carocci¹  Sabrina Buglioni¹  Sylvie M Renaud²  Alfonso Baldi³  Raffaele Murace⁴  Emanuele Dragonetti⁴  Gennaro Citro⁵  Enrico P Spugnini⁵  Pierluigi Cardelli⁶  Bruno Vincenzi⁷ 

[1] Ambulatorio Veterinario "Le Accademie", Rome, Italy;Ambulatorio Veterinario Renaud, Rome, Italy;Department of Biochemistry, Second University of Naples, Naples, Italy;Futura-Onlus, Rome, Italy;SAFU Department, Regina Elena Cancer Institute, Rome, Italy;Tor Vergata University, Rome, Italy;University Campus Biomedico, Rome, Italy;

关键词: Meloxicam;    Narrow Therapeutic Index;    Complete Blood Cell Count;    Serum Biochemistry Profile;    Feline Model;   

DOI  :  10.1186/1479-5876-9-152

 received in 2011-05-03, accepted in 2011-09-14,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundCancer is one of the most difficult current health challenges, being responsible for millions of deaths yearly. Systemic chemotherapy is the most common therapeutic approach, and the prevailing orientation calls for the administration of the maximum tolerated dose; however, considerable limitations exist including toxicities to healthy tissues and low achievable drug concentrations at tumor sites. Electrochemotherapy (ECT) is a tumor treatment that combines the systemic or local delivery of anticancer drugs with the application of permeabilizing electric pulses. In this article we evaluate the capability of ECT to allow the use of cisplatin despite its high toxicity in a spontaneous feline model of soft tissue sarcoma.MethodsA cohort of sixty-four cats with incompletely excised sarcomas were treated with cisplatin-based adjuvant ECT and monitored for side effects. Their response was compared to that of fourteen cats treated with surgery alone.ResultsThe toxicities were minimal and mostly treated symptomatically. ECT resulted in increased local control (median not reached at the time of writing) with a mean time to recurrence of 666 days versus 180 of controls.ConclusionsWe conclude that ECT is a safe and efficacious therapy for solid tumors; its use may be considered as part of strategies for the reintroduction of drugs with a narrow therapeutic index in the clinical protocols.

【 授权许可】

CC BY   
© Spugnini et al; licensee BioMed Central Ltd. 2011