BMC Infectious Diseases | |
Development of a prospective cohort of HIV Exposed Sero-Negative (HESN) individuals in Jos Nigeria | |
Research Article | |
Evaezi Okpokoro1  Ruth Datiri2  Pam Datong2  Grace Choji2  Felicia Okolo2  Sophia Osawe3  Alash’le Abimiku4  | |
[1] Institute of Human Virology (IHVN), Abuja, Nigeria;Plateau State Human Virology Research Centre (PLASVIREC), Jos, Nigeria;Plateau State Human Virology Research Centre (PLASVIREC), Jos, Nigeria;Institute of Human Virology (IHVN), Abuja, Nigeria;Plateau State Human Virology Research Centre (PLASVIREC), Jos, Nigeria;Institute of Human Virology (IHVN), Abuja, Nigeria;Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, USA; | |
关键词: HIV; HESN; Couples; Vaccine; Incidence; Nigeria; | |
DOI : 10.1186/s12879-016-1649-1 | |
received in 2015-11-02, accepted in 2016-06-08, 发布年份 2016 | |
来源: Springer | |
【 摘 要 】
BackgroundHIV/AIDS continues to be a global health problem. With currently no cure, it is critical to get an effective vaccine to add to the arsenal of prevention and treatment tools. HIV Exposed Sero-Negative (HESN) individuals were enrolled and followed for 2 years.MethodsA prospective observational cohort study to enroll HESN volunteers and their partners was developed with a 2-year follow up. This was a vaccine preparedness study and designed as a Phase IIb trial. We provided counseling, lab testing and conducted medical examinations for all enrollees.ResultsA total of 534 HESN were enrolled with 48 % (256) females and 52 % (278) males, a mean age of 37 ± 9 years. Three female HESN enrollees seroconverted giving this cohort a HIV incidence rate [95 % coefficient interval (CI)] of 3.2 (2.3–4.2) per 100,000 person-months of observation. Baseline analysis showed that female HESN are 24 % more likely to have their spouse consistently use condoms (RR 1.24; p = 0.04); 16 % more likely to have HIV+ partners with detectable viral load (RR 1.16, p = 0.03) and 28 % more likely that their HIV+ partners has a CD4 count less than 350cells/μl (RR 1.28, p = 0.03) when compared to male HESN.ConclusionsOur findings suggest that female HESN are more at risk of HIV acquisition due the low CD4 counts and detectable viral load among their HIV+ spouses. Moreover, we provide additional information on incidence and risk factors among naturally exposed persons, which might impact biomedical prevention research and immune responses to HIV vaccines.
【 授权许可】
CC BY
© The Author(s). 2016
【 预 览 】
Files | Size | Format | View |
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RO202311100250178ZK.pdf | 498KB | download |
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