Prognostic significance of XB130 expression in surgically resected pancreatic ductal adenocarcinoma

World Journal of Surgical Oncology

Research

Jian Zhang¹  Jianli Zhang¹  Xiuli Jiang² 

[1] Department of General Surgery, The Affiliated Hospital of Qingdao University, 59 Haier Road, 266000, Qingdao, Shandong Province, China;Department of Nutrition, The Affiliated Hospital of Qingdao University, 59 Haier Road, 266000, Qingdao, Shandong Province, China;

关键词: Pancreatic ductal adenocarcinoma;    Immunohistochemistry;    Prognosis;    XB130;   

DOI  :  10.1186/1477-7819-12-49

 received in 2013-12-14, accepted in 2014-02-19,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundXB130 is a newly discovered adaptor protein for intracellular signal transduction; it is involved in gene regulation, cell proliferation, cell survival, cell migration, and tumorigenesis. However, its expression and role in pancreatic ductal adenocarcinoma (PDAC) have not been investigated. The present study was designed to clarify the prognostic significance of XB130 expression in PDAC.MethodsA total of 76 consecutive patients with surgically resected PDAC were retrospectively reviewed. XB130 expression was detected by immunohistochemical analysis on the paraffin-embedded tumour sections. Correlation between the expression of XB130 and clinicopathological parameters was analyzed.ResultsXB130 expression was significantly upregulated in PDAC(56.5%, 43/76) compared to normal pancreas (0%, 0/15; P < 0.05). Increased XB130 expression was correlated with lymph node metastasis (P = 0.017), distant metastasis (P = 0.0024), high tumour-node-metastasis (TNM) stage (P =0.001), and high tumour grade (P = 0.013). The survival of 43 patients with high XB130 expression was significantly worse than that of the 33 patients with low XB130 expression (P = 0.001). Univariate analysis showed that high XB130 expression (P = 0.0045), tumour size (P = 0.024), distant metastasis (P = 0.003), TNM stage (P = 0.002) and lymphatic metastasis (P = 0.016) were independent prognostic factors of postoperative survival. Multivariate analysis using the Cox proportional hazards model showed that high XB130 expression and distant metastasis (P = 0.0239) were significant independent risk factors.ConclusionsXB130 was overexpressed in the PDAC. XB130 is a promising pathological marker for the prediction of outcome in patients with PDAC.

【 授权许可】

CC BY   
© Zhang et al.; licensee BioMed Central Ltd. 2014