Latent associations of low serum amylase with decreased plasma insulin levels and insulin resistance in asymptomatic middle-aged adults

Cardiovascular Diabetology

Original Investigation

Hiroshi Fuchigami¹  Hiromi Munakata²  Kei Nakajima³  Masanobu Kawakami⁴  Hitoshi Sugawara⁴  San-e Ishikawa⁴  Atsushi Aoki⁴  Shin-ichi Momomura⁴  Toshitaka Muneyuki⁴  Masashi Yoshida⁴  Masafumi Kakei⁴ 

[1] Department of Health Care Center, Social Insurance Omiya General Hospital, 453 Bonsai, 331-0805, Kita, Saitama, Japan;Department of Internal Medicine, Social Insurance Omiya General Hospital, 453, Bonsai, Kit, Japan;Division of Clinical Nutrition, Department of Medical Dietetics, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, 350-0295, Sakado, Saitama, Japan;Department of Internal Medicine, Social Insurance Omiya General Hospital, 453, Bonsai, Kit, Japan;First Department of Comprehensive Medicine, Saitama Medical Center, Jichi Medical University School of Medicine, 1-847 Amanuma, 330-8503, Omiya, Saitama, Japan;

关键词: Serum amylase;    Obesity;    Body mass index;    Insulin resistance;    Leptin;    75-g oral glucose tolerance test;    HOMA-R;    HOMA-β;    QUICKI;   

DOI  :  10.1186/1475-2840-11-80

 received in 2012-06-14, accepted in 2012-06-15,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundLow serum amylase is likely to be associated with obesity and metabolic abnormalities, which are often accompanied by impaired insulin action. However, it is unclear whether low serum amylase is associated with impaired insulin action in clinical settings. Therefore, we investigated the associations of low serum amylase with plasma insulin levels, and obesity-related parameters, including leptin.Research design and methodsWe measured serum amylase, plasma insulin, obesity-related parameters such as leptin, cardiometabolic risk factors, and anthropometric parameters in a cross-sectional study of 54 asymptomatic subjects (mean age 48.6 ± 7.6 years) who were not being treated for diabetes.ResultsBody mass index (BMI) and plasma glucose at 120 min after a 75-g oral glucose tolerance test (OGTT) were significantly higher in subjects with low serum amylase (< 60 IU/l, n = 21) than in those with normal-to-high serum amylase (n = 33) (P = 0.04 and P = 0.004, respectively). In univariate correlation analysis, serum amylase was significantly correlated with BMI alone (r = –0.39, P = 0.004). By contrast, multivariate logistic analysis showed that each 1-SD increase in quantitative insulin sensitivity check index, and each 1-SD decrease in plasma insulin OGTT at 0 and 60 min, homeostasis model assessment of insulin resistance (HOMA)-R, and HOMA-β were significantly associated with low serum amylase, particularly after adjusting for BMI. When subjects were divided into three groups according to HOMA-R, serum amylase levels were significantly lower in subjects with HOMA-R > 2.5 (n = 23) compared with subjects with HOMA-R 1.6–2.5 (n = 10) (61.1 ± 13.6 U/ml versus 76.9 ± 20.5 U/ml, Bonferroni test, P = 0.02), but not compared with subjects with HOMA-R<1.6 (n = 21; 62.7 ± 17.6 U/ml). Similar trends were observed when subjects were divided according to plasma leptin and fasting plasma insulin levels.ConclusionsThese results suggest that after adjusting for BMI, low serum amylase is associated with decreased basal insulin levels and insulin secretion, as well as high insulin resistance. The nature of these associations remains to be elucidated in further studies.

【 授权许可】

Unknown   
© Muneyuki et al. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.