Troponin release following endurance exercise: is inflammation the cause? a cardiovascular magnetic resonance study

Journal of Cardiovascular Magnetic Resonance

Research

Mat Wilson¹  Francisco D Alpendurada²  Dudley J Pennell²  Sanjay K Prasad²  Riccardo Wage²  Gillian Smith²  Rory O'Hanlon²  Joyce Wong²  Annette Dahl²  Sanjay Sharma³  Richard Godfrey⁴  Michael Roughton⁵  Keith George⁶  Greg Whyte⁷  Dave Oxborough⁸ 

[1] ASPETAR Qatar Orthopaedic and Sports Medicine Hospital, Qatar;Department of Cardiovascular Magnetic Resonance, Royal Brompton and Harefield NHS Foundation Trust, London, UK;Department of Heart Muscle Disorders, Kings College London, London, UK;Department of Sport and Exercise Science, Brunel University, Uxbridge, London, UK;R-Squared Statistics, London, UK;Research Institute for Sport and Exercise Science, Liverpool John Moore's University, Liverpool, UK;Research Institute for Sport and Exercise Science, Liverpool John Moore's University, Liverpool, UK;Centre for Sports Cardiology, Harley Street, London, UK;University of Leeds, Leeds, UK;

关键词: Cardiovascular Magnetic Resonance;    Myocardial Inflammation;    Late Gadolinium Enhancement;    Brain Natriuretic Peptide;    Endurance Exercise;   

DOI  :  10.1186/1532-429X-12-38

 received in 2010-06-22, accepted in 2010-07-02,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThe aetiology and clinical significance of troponin release following endurance exercise is unclear but may be due to transient myocardial inflammation. Cardiovascular magnetic resonance (CMR) affords us the opportunity to evaluate the presence of myocardial inflammation and focal fibrosis and is the ideal imaging modality to study this hypothesis. We sought to correlate the relationship between acute bouts of ultra endurance exercise leading to cardiac biomarkers elevation and the presence of myocardial inflammation and fibrosis using CMR.Methods17 recreation athletes (33.5 +/- 6.5 years) were studied before and after a marathon run with troponin, NTproBNP, and CMR. Specific imaging parameters to look for inflammation included T2 weighted images, and T1 weighted spin-echo images before and after an intravenous gadolinium-DTPA to detect myocardial hyperemia secondary to inflammation. Late gadolinium imaging was performed (LGE) to detect any focal regions of replacement fibrosis.ResultsEleven of the 17 participant had elevations of TnI above levels of cut off for myocardial infarction 6 hrs after the marathon (0.075 +/- 0.02, p = 0.007). Left ventricular volumes were reduced post marathon and a small increase in ejection fraction was noted (64+/- 1% pre, 67+/- 1.2% post, P = 0.014). Right ventricular volumes, stroke volume, and ejection fraction were unchanged post marathon. No athlete fulfilled criteria for myocardial inflammation based on current criteria. No regions of focal fibrosis were seen in any of the participants.ConclusionExercise induced cardiac biomarker release is not associated with any functional changes by CMR or any detectable myocardial inflammation or fibrosis.

【 授权许可】

CC BY   
© O'Hanlon et al; licensee BioMed Central Ltd. 2010