Estimating the malaria transmission of Plasmodium vivax based on serodiagnosis

Malaria Journal

Research

Youngjoo Sohn¹  Byoung-Kuk Na²  Hyuck Kim³  Hyeong-Woo Lee⁴  Yeon-Joo Kim⁵  Jung-Yeon Kim⁵  Tong-Soo Kim⁶  Hyung-Hwan Kim⁷ 

[1] Department of Anatomy, College of Oriental Medicine, Institue of Oriental Medicine, Kyung Hee University, Hoegi-dong, 130-701, Dongdaemun-gu, Seoul, Republic of Korea;Department of Parasitology and Institute of Health Sciences, Gyeongsang National University School of Medicine, 660-751, Jinju, Republic of Korea;Department of Parasitology, Inha University School of Medicine, 400-712, Incheon, Republic of Korea;Department of Pathology, University of Florida, J-566, 1275 Center Drive, 32610, Gainesville, FL, USA;Division of Malaria and Parasitic Diseases, Korea Centers for Disease Control and Prevention, 363-951, Osong, Republic of Korea;International Research Center for Bioscience and Biotechnology, Jungwon University, 367-805, Goesan, Republic of Korea;Vascular Medicine Research Unit, Brigham and Women's Hospital, Harvard Medical School, 02139, Cambridge, MA, USA;

关键词: Malaria;    Malaria Transmission;    Vivax Malaria;    Indirect Fluorescent Antibody Test;    High Positive Rate;   

DOI  :  10.1186/1475-2875-11-257

 received in 2012-05-23, accepted in 2012-07-22,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundPlasmodium vivax re-emerged in 1993 and has now become a major public health problem during the summer season in South Korea. The aim of this study was to interpret and understand the meaning of seroepidemiological studies for developing the best malaria control programme in South Korea.MethodsBlood samples were collected in Gimpo city, Paju city, Yeoncheon County, Cheorwon County and Goseong County of high risk area in South Korea. Microscopy was performed to identify patients infected with P. vivax. Antibody detection for P. vivax was performed using indirect fluorescent antibody test (IFAT).ResultsA total of 1,574 blood samples was collected from participants in the study areas and evaluated against three parameters: IFAT positive rate, annual antibody positive index (AAPI), and annual parasite index (API). The IFAT positive rate was 7.24% (n = 114). Of the five study areas, Gimpo had the highest IFAT positive rate (13.68%) and AAPI (4.63). Yeongcheon had the highest API in 2005 (2.06) while Gimpo had the highest API in 2006 (5.00). No correlation was observed between any of the three parameters and study sites' distance from the demilitarized zone (DMZ).ConclusionsThese results showed that P. vivax antibody levels could provide useful information about the prevalence of malaria in endemic areas. Furthermore, AAPI results for each year showed a closer relationship to API the following year than the API of the same year and thus could be helpful in predicting malaria transmission risks.

【 授权许可】

CC BY   
© Kim et al.; licensee BioMed Central Ltd. 2012