Incidence of acute pulmonary embolism, related comorbidities and survival; analysis of a Swedish national cohort

BMC Cardiovascular Disorders

Research Article

Stefan Söderberg¹  Therese Andersson¹ 

[1] Department of Public Health and Clinical Medicine, Medicine, Umea University, -90187, Umeå, SE, Sweden;

关键词: Pulmonary embolism;    Incidence;    Comorbidities;    Prognosis;    Sweden;   

DOI  :  10.1186/s12872-017-0587-1

 received in 2016-09-07, accepted in 2017-06-02,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe aim of the study was to determine the incidence of acute pulmonary embolism (PE) in Sweden and any regional differences. To assess short- and long-term survival analysis after an episode of PE, before and after excluding patients with known malignancies, and to determine the most common comorbidities prior to the PE event.MethodsAll in-hospital patients, including children, diagnosed with acute PE in 2005 were retrieved from the Swedish National Patient Registry (NPR) and incidence rates were calculated. All registered comorbidities from 1998 until the index events were collected and survival up to 4 years after the event were calculated and compared to matched controls.ResultsThere were 5793 patients of all ages diagnosed with acute PE in 2005 resulting in a national incidence of 0.6/1000/year. The mean age was 70 years and 52% were women. The most frequent comorbidities were cardiac-, vascular-, infectious- and gastrointestinal diseases, injuries and malignancies. The mortality rates were more than doubled in patients with recent PE compared to that in a matched control group (49.1% vs 21.9%), and the excess mortality remained after exclusion of deaths occurring within one year and after exclusion of patients with any malignancy prior to the event.ConclusionsPE is associated with high age as well as with multiple comorbidities, and with an increased short- and long-term mortality. This study highlights the importance of a proper follow-up after an acute PE.

【 授权许可】

CC BY   
© The Author(s). 2017