Association between serum insulin-like growth factor I or IGF-binding protein 3 and estimated glomerular filtration rate: results of a population-based sample

BMC Nephrology

Research Article

Sylvia Stracke¹  Henry Völzke²  Karlhans Endlich³  Kathleen Dittmann⁴  Matthias Nauck⁴  Nele Friedrich⁴  Henri Wallaschofski⁴  Rainer Rettig⁵ 

[1] Department of Internal Medicine A, Ernst-Moritz-Arndt University of Greifswald, Greifswald, Germany;Institute for Community Medicine, Ernst-Moritz-Arndt University of Greifswald, Greifswald, Germany;Institute of Anatomy and Cell Biology, Ernst-Moritz-Arndt University of Greifswald, Greifswald, Germany;Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt University of Greifswald, Greifswald, Germany;Institute of Physiology, Ernst-Moritz-Arndt University of Greifswald, Greifswald, Germany;

关键词: eGFR;    Insulin-like growth factor;    IGF-I;    IGFBP-3;    Renal function;    Study of health in Pomerania;   

DOI  :  10.1186/1471-2369-13-169

 received in 2012-04-19, accepted in 2012-12-07,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundInsulin-like growth factor I (IGF-I), which is mostly carried in blood by IGF-binding protein 3 (IGFBP-3), was associated to the glomerular filtration rate and chronic kidney disease in a multiethnic study among US adults. The aim of the present study was to investigate whether serum IGF-I or IGFBP-3 are associated with estimated glomerular filtration rate (eGFR) in a population-based study of Caucasian adults.MethodsData from 4028 subjects (2048 women) aged 20 to 81 years from the Study of Health in Pomerania (SHIP) were analyzed. Total serum IGF-I and IGFBP-3 concentrations were determined by chemiluminescence immunoassays and categorized into sex- and age-specific quartiles.ResultsAfter adjusting for age, waist circumference and type 2 diabetes mellitus, analysis of variance (ANOVA) revealed inverse associations between serum IGF-I concentrations and eGFR in men as well as between serum IGFBP-3 concentrations and eGFR in men and women. Logistic regression analyses confirmed these findings and showed that high IGF-I or IGFBP-3 concentrations were associated with an increased risk of decreased eGFR (<60 mL/min/1.73 m2) in men or women. These relations became stronger when lower eGFR cut-offs were used for the analyses.ConclusionOur data revealed associations of increased serum IGF-I concentrations and decreased eGFR in men but not in women and an association of increased serum IGFBP-3 concentrations and decreased eGFR in both sexes.

【 授权许可】

CC BY   
© Dittmann et al.; licensee BioMed Central Ltd. 2012