Cryoballoon vs. open irrigated radiofrequency ablation for paroxysmal atrial fibrillation: long-term FreezeAF outcomes

BMC Cardiovascular Disorders

Research Article

Peter Bramlage¹  Kevin Kunzmann²  Meinhard Kieser²  Andrea Radzewitz³  Kerstin Schmidt³  Matthias Merkel³  Claus Schmitt³  Thomas Schenk³  Patrick Hörmann³  Gerhard Schymik³  Armin Luik³ 

[1] Institute for Pharmacology and Preventive Medicine, Mahlow, Germany;Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany;Medizinische Klinik IV, Städtisches Klinikum Karlsruhe, Academic Teaching Hospital of the University of Freiburg, Karlsruhe, Germany;

关键词: Atrial fibrillation;    Catheter ablation;    Radiofrequency;    Cryoablation;    Cryoballoon;    Pulmonary vein isolation;   

DOI  :  10.1186/s12872-017-0566-6

 received in 2017-03-03, accepted in 2017-05-11,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundEffective treatment of paroxysmal atrial fibrillation (AF) is essential for reducing the risk of stroke and heart failure. Cryoballoon (CB) ablation has been developed as an alternative to the use of radiofrequency (RF) energy for electrical isolation of the pulmonary veins. Herein, we provide long-term data regarding the efficacy of CB ablation in comparison to RF.MethodsFreezeAF was a randomised non-inferiority study comparing CB ablation with RF ablation for the treatment of patients with drug-refractory paroxysmal AF. Procedural success for the long-term follow-up (30 months) was defined as freedom from AF with an absence of persistent complications.ResultsOf the 315 patients that were randomised and received catheter ablation, 292 (92.7%) completed the 30-month follow-up (147 in the RF group and 145 in the CB group). The baseline characteristics of the RF and CB groups were similar. Single-procedure success was achieved by 40% of patients in the RF group and 42% of the CB group (p < 0.001 for non-inferiority). When including re-do procedures in the analysis, the multiple procedure success rate was 72% in the RF group and 76% in the CB group.ConclusionThe data provide long-term evidence that CB ablation is non-inferior to RF ablation, with high proportions of patients reporting freedom from AF 30 months after the index procedure.Trial registrationClinicalTrials.gov Identifier: NCT00774566; first registered October 16, 2008; first patient included October 20, 2008.

【 授权许可】

CC BY   
© The Author(s). 2017