Epidemiological and molecular characteristics of emergent dengue virus in Yunnan Province near the China-Myanmar-Laos border, 2013–2015

BMC Infectious Diseases

Research Article

Fu-Qiang Zhang¹  Jing Yu¹  Tian Tang¹  Quan-Shui Fan¹  Liu Zhang¹  Gang Chen¹  Ting-Song Hu²  Hai-Lin Zhang³  Hua-Chang Li⁴  Xiao-Xiong Yin⁵  Yong-Hua Liu⁵  Jian-Hua Fan⁶  Hong-Bin Li⁶  Jin Zu⁶  Yuan-Yuan Li⁶  Yun Feng⁷ 

[1]Center for Disease Control and Prevention, Chengdu Military Region, 168 Daguan Road, 650032, Kunming, People’s Republic of China

[2]Center for Disease Control and Prevention, Chengdu Military Region, 168 Daguan Road, 650032, Kunming, People’s Republic of China

[3]The Postdoctoral Programme of Kunming General Hospital, Chengdu Military Region, Kunming, People’s Republic of China

[4]Center for Disease Control and Prevention, Chengdu Military Region, 168 Daguan Road, 650032, Kunming, People’s Republic of China

[5]Yunnan Institute of Endemic Diseases Control and Prevention, Dali, Yunnan, People’s Republic of China

[6]Lincang Center for Disease Control and Prevention, Lincang, Yunnan, People’s Republic of China

[7]Ruili Center for Disease Control and Prevention, Ruili, Yunnan, People’s Republic of China

[8]Xishuangbanna Center for Disease Control and Prevention, Jinghong, Yunnan, People’s Republic of China

[9]Yunnan Institute of Endemic Diseases Control and Prevention, Dali, Yunnan, People’s Republic of China

关键词: Dengue fever;    Dengue virus;    Molecular epidemiology;    Public health;    E gene;    Homology;    Phylogenetic analysis;   

DOI  :  10.1186/s12879-017-2401-1

 received in 2016-10-21, accepted in 2017-04-12,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundYunnan Province is located in southwestern China and neighbors the Southeast Asian countries, all of which are dengue-endemic areas. In 2000–2013, sporadic imported cases of dengue fever (DF) were reported almost annually in Yunnan Province. During 2013–2015, we confirmed that a large-scale indigenous DF outbreak emerged in cities of Yunnan Province near the China-Myanmar-Laos border.MethodsEpidemiological characteristics of DF in Yunnan Province during 2013–2015 were evaluated by retrospective analysis. A total of 232 dengue virus (DENV)-positive sera were randomly collected for sequence analysis of the capsid/premembrane region of DENV from patients with DF in Yunnan Province. The envelope gene of DENV isolates was also amplified and sequenced. Phylogenetic analyses were performed using the neighbor-joining method with the Tajima-Nei model.ResultsPhylogenetically, all DENV-positive samples could be classified into DENV-1 genotype I and DENV-2 Asian I genotype during 2013–2015 and DENV-4 genotype I in 2015 from Ruili City; and DENV-3 genotype II in 2013 and DENV-2 Cosmopolitan genotype in 2015 from Xishuangbanna Prefecture.ConclusionsOur results indicated that imported DF from patients from Laos and Myanmar was the primary cause of the DF epidemic in Yunnan Province. Additionally, DENV strains of all four serotypes were identified in indigenous cases in Yunnan Province during the same time period, while the dengue epidemic pattern observed in southwestern Yunnan showed characteristics of a hypoendemic nature: circulation of DENV-1 and DENV-2 over consecutive years.

【 授权许可】

CC BY   
© The Author(s). 2017