Risk factors for new-onset diabetes mellitus after living donor kidney transplantation in Korea - a retrospective single center study

BMC Nephrology

Research Article

Duck Jong Han¹  Seung Don Baek²  Su-Kil Park²  Chung Hee Baek²  Soomin Jeung²  Hyosang Kim²  Hoon Yu³ 

[1] Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea;Division of a Nephrology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea;Division of a Nephrology, Gangneung Asan hospital, University of Ulsan College of Medicine, Gangneung, South Korea;

关键词: Diabetes mellitus;    Kidney Transplantation;    Magnesium;    Tacrolimus;   

DOI  :  10.1186/s12882-016-0321-8

 received in 2016-03-19, accepted in 2016-07-21,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundNew-onset diabetes mellitus after transplantation (NODAT) is a serious complication following renal transplantation. The aim of this study was to identify the risk factors for the development of NODAT in Korean transplant patients.MethodsRecipients who underwent living donor kidney transplantation between January 2009 and April 2012 at Asan Medical Center were reviewed. Diagnosis of NODAT was defined according to the American Diabetes Association criteria.ResultsA total of 418 patients were enrolled. NODAT was diagnosed in 85 (20.4 %) patients within 1 year. By multivariate analysis, old age (odds ratio [OR], 1.05; 95 % Confidence interval [CI]: 1.01–1.08), family history of diabetes mellitus (OR, 2.48; 95 % CI: 1.04–5.94), pre-transplant high serum glucose level (OR, 1.04; 95 % CI: 1.01–1.08), and obesity (OR, 3.46; 95 % CI: 1.55–7.73) were independent risk factors for NODAT.ConclusionOld age, family history of diabetes, pre-transplant high plasma glucose level, and obesity are independent factors associated with the development of diabetes after renal transplantation. In contrast, serum magnesium levels and the use of tacrolimus are not associated with the development of NODAT.

【 授权许可】

CC BY   
© The Author(s). 2016