Interaction between alcohol drinking and obesity in relation to colorectal cancer risk: a case-control study in Newfoundland and Labrador, Canada

BMC Public Health

Research Article

Patrick S Parfrey¹  Zhuoyu Sun²  Jinhui Zhao²  Sharon Buehler²  Josh Squires²  Barbara Roebothan²  Roy West²  Peizhong Peter Wang³  Yun Zhu³  Peter T Campbell⁴  John R McLaughlin⁵ 

[1] Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, 300 Prince Philip Drive, A1B 3V6, St. John's, NL, Canada;Division of Community Health and Humanities, Faculty of Medicine, Memorial University of Newfoundland, 300 Prince Philip Drive, A1B 3V6, St. John's, NL, Canada;Division of Community Health and Humanities, Faculty of Medicine, Memorial University of Newfoundland, 300 Prince Philip Drive, A1B 3V6, St. John's, NL, Canada;School of Public Health, Tianjin Medical University, 22 Qi Xiangtai Road, 300070, Tianjin, China;Epidemiology Research Program, American Cancer Society, 250 Williams Street NW, 30303, Atlanta, GA, USA;Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 60 Murray Street #L5-211, M5T 3L9, Toronto, ON, Canada;

关键词: Case-control study;    Alcohol;    Obesity;    Colorectal cancer;    Interaction;    Lifestyles;    Newfoundland;   

DOI  :  10.1186/1471-2458-12-94

 received in 2011-10-16, accepted in 2012-02-01,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundWhile substantive epidemiological literature suggests that alcohol drinking and obesity are potential risk factors of colorectal cancer (CRC), the possible interaction between the two has not been adequately explored. We used a case-control study to examine if alcohol drinking is associated with an increased risk of CRC and if such risk differs in people with and without obesity.MethodsNewly diagnosed CRC cases were identified between 1999 and 2003 in Newfoundland and Labrador (NL). Cases were frequency-matched by age and sex with controls selected using random digit dialing. Cases (702) and controls (717) completed self-administered questionnaires assessing health and lifestyle variables. Estimates of alcohol intake included types of beverage, years of drinking, and average number of alcohol drinks per day. Odds ratios were estimated to investigate the associations of alcohol independently and when stratified by obesity status on the risk of CRC.ResultsAmong obese participants (BMI ≥ 30), alcohol was associated with higher risk of CRC (OR: 2.2; 95% CI: 1.2-4.0) relative to the non-alcohol category. Among obese individuals, 3 or more different types of drinks were associated with a 3.4-fold higher risk of CRC relative to non-drinkers. The risk of CRC also increased with drinking years and drinks daily among obese participants. However, no increased risk was observed in people without obesity.ConclusionThe effect of alcohol of drinking on CRC seems to be modified by obesity.

【 授权许可】

Unknown   
© Zhao et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.