Incidental gastrointestinal 18F-Fluorodeoxyglucose uptake associated with lung cancer

BMC Pulmonary Medicine

Research Article

Thibault Lestra¹  Dimitri Papathanassiou¹  Louis Boissiere²  François Lebargy²  Hervé Vallerand²  Gaëtan Deslee²  Claire Launois²  Jeanne-Marie Perotin²  Juliette Vella-Boucaud²  Sandra Dury²  Mathilde Brasseur³  Olivier Bouche⁴  Alain Prevost⁵ 

[1] Service de Médecine Nucléaire, Institut Jean Godinot, Centre de Lutte Contre le Cancer à Reims, Reims, France;Service des Maladies Respiratoires, Hôpital Maison Blanche, CHU de Reims, 45 rue Cognacq Jay, 51092, Cedex, Reims, France;Service d’Hépato-Gastro-Entérologie et Cancérologie Digestive, Hôpital Robert Debré, CHU de Reims, Reims, France;Service d’Hépato-Gastro-Entérologie et Cancérologie Digestive, Hôpital Robert Debré, CHU de Reims, Reims, France;Unité de Médecine Ambulatoire Cancérologie Hématologie, Hôpital Robert Debré, CHU Reims, Reims, France;Service d’Oncologie Médicale, Institut Jean Godinot, Centre de Lutte Contre le Cancer à Reims, Reims, France;

关键词: Gastrointestinal Tract;    Incidental Findings;    Lung Neoplasms;    Fluorodeoxyglucose F18;    Positron Emission Tomography;   

DOI  :  10.1186/s12890-015-0152-6

 received in 2015-04-25, accepted in 2015-11-25,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundF-Fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is increasingly used for the initial staging and restaging of lung cancer. Incidental gastrointestinal findings are often observed on 18F-FDG PET/CT. The objective of this study was to assess incidental 18F-FDG uptake by the gastrointestinal tract (GIT) in patients with lung cancer.MethodsTwo hundred thirty consecutive 18F-FDG PET/CT examinations performed for lung cancer over a 3-year period were retrospectively reviewed for the presence of incidental FDG uptake in the GIT. The charts of patients with positive FDG uptake were then reviewed and analysed to determine the GIT uptake sites, the standardized uptake value (SUV) max and the final clinical diagnosis.ResultsFifty-two patients (52/230, 23 %) demonstrated incidental FDG uptake in the GIT. Thirty-three patients (63.5 %) had diffuse uptake (oesophagus, n = 2, colon, n = 31) and 19 patients (36.5 %) had focal uptake (oesophagus, n = 1, small bowel, n = 1, ascending colon, n = 5, descending colon, n = 4, sigmoid, n = 4, rectum, n = 3, and anal margin, n = 1). Twelve of the 52 patients with GIT uptake were further investigated, revealing, a diagnosis of malignancy in 4 patients with focal FDG uptake. No significant differences in mean SUVmax were observed between patients with malignant and benign GIT diseases.ConclusionThis study demonstrates a high incidence of FDG uptake in the GIT associated with lung cancer. Focal GIT uptake was frequently associated with malignant disease. These results suggest that further GIT investigations should be performed in patients with focal GIT uptake.

【 授权许可】

CC BY   
© Vella-Boucaud et al. 2015