The DAOA/G30 locus and affective disorders: haplotype based association study in a polydiagnostic approach

BMC Psychiatry

Research Article

Meinhard Mende¹  Sven Jung²  Gerald Stöber³  Bruno Pfuhlmann³  Micha Gawlik³  Ingeborg Wehner³  Michael Knapp⁴ 

[1] Coordination Centre for Clinical Trials, University of Leipzig, Härtelstraße 16-18, 04107, Leipzig, Germany;Department of Forensic Medicine, University of Würzburg, Lindleinstraße 15, 97080, Würzburg, Germany;Department of Psychiatry and Psychotherapy, University of Würzburg, Füchsleinstraße 15, 97080, Würzburg, Germany;Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany;

关键词: Schizophrenia;    Affective Disorder;    Bipolar Depression;    Linkage Disequilibrium Block;    Bipolar Affective Disorder;   

DOI  :  10.1186/1471-244X-10-59

 received in 2009-10-15, accepted in 2010-07-29,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThe DAOA/G30 (D-amino acid oxidase activator) gene complex at chromosomal region 13q32-33 is one of the most intriguing susceptibility loci for the major psychiatric disorders, although there is no consensus about the specific risk alleles or haplotypes across studies.MethodsIn a case-control sample of German descent (affective psychosis: n = 248; controls: n = 188) we examined seven single nucleotide polymorphisms (SNPs) around DAOA/G30 (rs3916966, rs1935058, rs2391191, rs1935062, rs947267, rs3918342, and rs9558575) for genetic association in a polydiagnostic approach (ICD 10; Leonhard's classification).ResultsNo single marker showed evidence of overall association with affective disorder neither in ICD10 nor Leonhard's classification. Haplotype analysis revealed no association with recurrent unipolar depression or bipolar disorder according to ICD10, within Leonhard's classification manic-depression was associated with a 3-locus haplotype (rs2391191, rs1935062, and rs3916966; P = 0.022) and monopolar depression with a 5-locus combination at the DAOA/G30 core region (P = 0.036).ConclusionOur data revealed potential evidence for partially overlapping risk haplotypes at the DAOA/G30 locus in Leonhard's affective psychoses, but do not support a common genetic contribution of the DAOA/G30 gene complex to the pathogenesis of affective disorders.

【 授权许可】

CC BY   
© Gawlik et al; licensee BioMed Central Ltd. 2010