No association between polymorphisms of WNT2and schizophrenia in a Korean population

BMC Medical Genetics

Research Article

Hak-Jae Kim¹  Hyun-Kyung Park²  Ji Young Song³  Jong Woo Kim³  Jin Kyung Park³  Ah-Rang Cho³  Su Kang Kim⁴  Sung Wook Kang⁴  Joo-Ho Chung⁴ 

[1] College of Medicine, Soonchunhyang University, 336-745, Chunan, South Korea;Department of Emergency Medicine, East-West Neo-media Center, Kyung Hee University, 149 Sang-il dong, Gangdong-gu, 134-727, Seoul, South Korea;Department of Neuropsychiatry, School of Medicine, Kyung Hee University, 130-701, Seoul, South Korea;Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, 130-701, Seoul, South Korea;

关键词: Schizophrenia;    Schizophrenic Patient;    Schizophrenia Patient;    Brief Psychiatric Rate Scale;    Linkage Disequilibrium Block;   

DOI  :  10.1186/1471-2350-11-78

 received in 2009-10-07, accepted in 2010-05-24,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundWingless-type MMTV integration site family member 2 (WNT2) has a potentially important role in neuronal development; however, there has yet to be an investigation into the association between single nucleotide polymorphisms (SNPs) of WNT2 and schizophrenia. This study aimed to determine whether certain SNPs of WNT2 were associated with schizophrenia in a Korean population.Methodse genotyped 7 selected SNPs in the WNT2 gene region (approximately 46 Kb) using direct sequencing in 288 patients with schizophrenia and 305 healthy controls.ResultsOf the SNPs examined, one SNP showed a weak association with schizophrenia (p = 0.017 in the recessive model). However, this association did not remain statistically significant after Bonferroni correction.ConclusionThe present study does not support a major role for WNT2 in schizophrenia. This could be due to the size of the population. Therefore, additional studies would be needed to definitively rule out the gene's minor effects.

【 授权许可】

Unknown   
© Kim et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.